Disease relevance of Oc90

• The corresponding gene, termed PLA2L, is also unusual in that it is transcribed from an endogenous retroviral long terminal repeat promoter in teratocarcinoma cell lines [1].

High impact information on Oc90

• 5. The encoded 95-kDa glycoprotein is the major protein of the utricular and saccular otoconia and thus was named otoconin-95 [2].
• By immunohistofluorescence, otoconin-95 also was detected in the cupulae of the semicircular canals and in previously undescribed transient granular structures of the cochlea [2].
• Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals [2].
• Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15 [3].
• Deletions encompassing the Oc 90 and Sox 10 loci were transmitted to the offspring of the chimeric mice that were generated from deletion-bearing ES cells [4].

Biological context of Oc90

• Otoconin-90, the principal otoconial matrix protein, provided a tool to investigate the molecular mechanism of otoconial morphogenesis [5].

Anatomical context of Oc90

• Otoconin-90 was also localized at the surface and the interior of epithelial cells lining the endolymphatic sac as well as incorporated into free floating cells [5].

Associations of Oc90 with chemical compounds

• Because of ample expression of otoconin-90 protein in the absence of the corresponding mRNA, we conclude that the luminal otoconin-90 is imported via longitudinal flow from the vestibular compartments, where both mRNA and protein are strongly expressed [5].

References