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Gene Review

Twf1  -  twinfilin, actin-binding protein, homolog...

Mus musculus

Synonyms: A6, Protein A6, Ptk9, Twinfilin-1, actin monomer-binding protein, ...
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High impact information on Twf1


Biological context of Twf1

  • The identification of a potential actin/phosphoinositide binding domain and consensus phosphorylation sites, coupled with A6's expression in a variety of cell types suggest that the A6 gene product may play a role in basic cellular processes [6].
  • Here, we isolated a mouse A6 cDNA clone from a murine myeloid progenitor 32D cell library using a 1.1 kb cDNA probe containing the entire human A6 open reading frame (ORF) [6].

Anatomical context of Twf1


Other interactions of Twf1


  1. Mouse A6/twinfilin is an actin monomer-binding protein that localizes to the regions of rapid actin dynamics. Vartiainen, M., Ojala, P.J., Auvinen, P., Peränen, J., Lappalainen, P. Mol. Cell. Biol. (2000) [Pubmed]
  2. Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. Vartiainen, M.K., Sarkkinen, E.M., Matilainen, T., Salminen, M., Lappalainen, P. J. Biol. Chem. (2003) [Pubmed]
  3. The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. Li, F., Higgs, H.N. Curr. Biol. (2003) [Pubmed]
  4. Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis. Kwiatkowski, D.J., Bruns, G.A. J. Biol. Chem. (1988) [Pubmed]
  5. Solution structure of coactosin reveals structural homology to ADF/cofilin family proteins. Hellman, M., Paavilainen, V.O., Naumanen, P., Lappalainen, P., Annila, A., Permi, P. FEBS Lett. (2004) [Pubmed]
  6. Cloning and characterization of the mouse homolog of the human A6 gene. Beeler, J.F., Patel, B.K., Chedid, M., LaRochelle, W.J. Gene (1997) [Pubmed]
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