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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Granulocyte Precursor Cells

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Disease relevance of Granulocyte Precursor Cells


High impact information on Granulocyte Precursor Cells

  • Since NE is maximally produced in promyelocytes, this protease may play a role in APL pathogenesis by facilitating the leukemogenic potential of PML-RARalpha [6].
  • Ectopic expression of GBX2 in growth factor-dependent myeloblasts induces monocytic features and independence from exogenous cytokines, reflecting distinct features of AMV-transformed cells [7].
  • These observations indicate that expression of Egr-1 is essential for and restricts differentiation of myeloblasts along the macrophage lineage [8].
  • Treatment with RA would not only relieve this inhibition, but the activated PML-RAR protein may actually promote myelocyte differentiation [9].
  • In freeze-thawing experiments, 39 pg of parathyroid hormone was released form 1 x 108 of the patient's myeloblasts; no hormone was released from the normocalcemia cells [10].

Chemical compound and disease context of Granulocyte Precursor Cells


Biological context of Granulocyte Precursor Cells

  • To study its role during hematopoiesis, we have generated primary chicken myeloblasts expressing different dominant-negative (dn) alleles of Stat5 [16].
  • These double-labeled slides were utilized to determine the duration of S-phase (Ts) in myeloblasts and their total cell cycle time (Tc) [17].
  • Unexpectedly, we observed that an RXR-specific, rather than an RAR-specific, agonist induces terminal granulocytic differentiation of MPRO promyelocytes, and this differentiation is associated with activation of DNA response elements corresponding to RAR-RXR heterodimers rather than RXR-RXR homodimers [18].
  • The c-kit proto-oncogene has been shown to be expressed by leukemic myeloblasts, but not by normal unseparated human bone marrow cells [19].
  • A cDNA library was constructed from HL60 human promyelocyte poly(A)+ RNA harvested 3 h after induction of macrophage differentiation with 12-O-tetradecanoyl phorbol-13-acetate in the presence of cycloheximide [20].

Anatomical context of Granulocyte Precursor Cells


Associations of Granulocyte Precursor Cells with chemical compounds

  • The rationale is based on a) evidence that, following drug-induced aplasia, resultant bone marrow proliferation in vivo corresponds temporally with induced humoral stimulatory activity, and on b) models that demonstrate increased cytotoxicity of beta-cytosine arabinoside (Ara-C) to myeloblasts cultured in humoral stimulatory activity (HSA) [26].
  • We have previously demonstrated that continuous exposure of human HL-60 human promyelocytes to 1-beta-D-arabinofuranosylcytosine (ara-C) results in the induction of terminal differentiation to monocyte-like cells [27].
  • An extract from the promyelocytes reduced significantly (P less than 0.001) the ouabain-insensitive sodium efflux rate, from 0.096 +/- 0.009 to 0.056 +/- 0.003 SD [28].
  • Production of a cytotoxin from phorbol myristate acetate-treated human promyelocytes [29].
  • Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA [30].

Gene context of Granulocyte Precursor Cells


Analytical, diagnostic and therapeutic context of Granulocyte Precursor Cells


  1. Proliferating cell nuclear antigen in blast crisis cells of patients with chronic myeloid leukemia. Takasaki, Y., Robinson, W.A., Tan, E.M. J. Natl. Cancer Inst. (1984) [Pubmed]
  2. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Moog-Lutz, C., Cavé-Riant, F., Guibal, F.C., Breau, M.A., Di Gioia, Y., Couraud, P.O., Cayre, Y.E., Bourdoulous, S., Lutz, P.G. Blood (2003) [Pubmed]
  3. Cyclin A1 expression in leukemia and normal hematopoietic cells. Yang, R., Nakamaki, T., Lübbert, M., Said, J., Sakashita, A., Freyaldenhoven, B.S., Spira, S., Huynh, V., Müller, C., Koeffler, H.P. Blood (1999) [Pubmed]
  4. Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. Sperr, W.R., Jordan, J.H., Baghestanian, M., Kiener, H.P., Samorapoompichit, P., Semper, H., Hauswirth, A., Schernthaner, G.H., Chott, A., Natter, S., Kraft, D., Valenta, R., Schwartz, L.B., Geissler, K., Lechner, K., Valent, P. Blood (2001) [Pubmed]
  5. Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin. Alcantara, O., Obeid, L., Hannun, Y., Ponka, P., Boldt, D.H. Blood (1994) [Pubmed]
  6. Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice. Lane, A.A., Ley, T.J. Cell (2003) [Pubmed]
  7. The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. Kowenz-Leutz, E., Herr, P., Niss, K., Leutz, A. Cell (1997) [Pubmed]
  8. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Nguyen, H.Q., Hoffman-Liebermann, B., Liebermann, D.A. Cell (1993) [Pubmed]
  9. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Kakizuka, A., Miller, W.H., Umesono, K., Warrell, R.P., Frankel, S.R., Murty, V.V., Dmitrovsky, E., Evans, R.M. Cell (1991) [Pubmed]
  10. Acute myelobalstic leukemia and hypercalcemia. A case of probable ectopic parathyroid hormone production. Zidar, B.L., Shadduck, R.K., Winkelstein, A., Zeigler, Z., Hawker, C.D. N. Engl. J. Med. (1976) [Pubmed]
  11. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Grisolano, J.L., Wesselschmidt, R.L., Pelicci, P.G., Ley, T.J. Blood (1997) [Pubmed]
  12. Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in neoplastic and normal cells. Lauzon, G.J., Paterson, A.R., Belch, A.W. Cancer Res. (1978) [Pubmed]
  13. Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. Boland, M.P., Foster, S.J., O'Neill, L.A. J. Biol. Chem. (1997) [Pubmed]
  14. Effect of pharmacologically relevant concentrations of mitoxantrone on the in vitro growth of leukemic blast progenitors. Grant, S., Arlin, Z., Gewirtz, D., Feldman, E. Leukemia (1991) [Pubmed]
  15. A fludarabine-based protocol for bone marrow transplantation in Fanconi's anemia. Kapelushnik, J., Or, R., Slavin, S., Nagler, A. Bone Marrow Transplant. (1997) [Pubmed]
  16. Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Kieslinger, M., Woldman, I., Moriggl, R., Hofmann, J., Marine, J.C., Ihle, J.N., Beug, H., Decker, T. Genes Dev. (2000) [Pubmed]
  17. Differences in cell cycle characteristics among patients with acute nonlymphocytic leukemia. Raza, A., Maheshwari, Y., Preisler, H.D. Blood (1987) [Pubmed]
  18. Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation. Johnson, B.S., Chandraratna, R.A., Heyman, R.A., Allegretto, E.A., Mueller, L., Collins, S.J. Mol. Cell. Biol. (1999) [Pubmed]
  19. c-kit expression by CD34+ bone marrow progenitors and inhibition of response to recombinant human interleukin-3 following exposure to c-kit antisense oligonucleotides. Catlett, J.P., Leftwich, J.A., Westin, E.H., Grant, S., Huff, T.F. Blood (1991) [Pubmed]
  20. Regulation of the mRNA for monocyte-derived neutrophil-activating peptide in differentiating HL60 promyelocytes. Kowalski, J., Denhardt, D.T. Mol. Cell. Biol. (1989) [Pubmed]
  21. Expression of cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation. Robinson, J., Sieff, C., Delia, D., Edwards, P.A., Greaves, M. Nature (1981) [Pubmed]
  22. Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development. Tsai, S., Bartelmez, S., Sitnicka, E., Collins, S. Genes Dev. (1994) [Pubmed]
  23. Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage. Porse, B.T., Bryder, D., Theilgaard-Mönch, K., Hasemann, M.S., Anderson, K., Damgaard, I., Jacobsen, S.E., Nerlov, C. J. Exp. Med. (2005) [Pubmed]
  24. Inhibition of c-fes expression by an antisense oligomer causes apoptosis of HL60 cells induced to granulocytic differentiation. Manfredini, R., Grande, A., Tagliafico, E., Barbieri, D., Zucchini, P., Citro, G., Zupi, G., Franceschi, C., Torelli, U., Ferrari, S. J. Exp. Med. (1993) [Pubmed]
  25. Kinetics of human hemopoietic cells after in vivo administration of granulocyte-macrophage colony-stimulating factor. Aglietta, M., Piacibello, W., Sanavio, F., Stacchini, A., Aprá, F., Schena, M., Mossetti, C., Carnino, F., Caligaris-Cappio, F., Gavosto, F. J. Clin. Invest. (1989) [Pubmed]
  26. Chemotherapy of leukemia in mice, rats, and humans relating time of humoral stimulation, tumor growth, and clinical response. Burke, P.J., Karp, J.E., Vaughan, W.P. J. Natl. Cancer Inst. (1981) [Pubmed]
  27. Induction of terminal differentiation in human K562 erythroleukemia cells by arabinofuranosylcytosine. Luisi-DeLuca, C., Mitchell, T., Spriggs, D., Kufe, D.W. J. Clin. Invest. (1984) [Pubmed]
  28. Isolation of a sodium transport inhibitory factor, inhibitin, from cultured leukemic promyelocytes. Morgan, K., Mir, M.A. J. Clin. Invest. (1984) [Pubmed]
  29. Production of a cytotoxin from phorbol myristate acetate-treated human promyelocytes. Gifford, G.E., Flick, D.A., AbdAllah, N.A., Fisch, H. J. Natl. Cancer Inst. (1984) [Pubmed]
  30. Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA. Major, P.P., Egan, E.M., Beardsley, G.P., Minden, M.D., Kufe, D.W. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  31. AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. Schwieger, M., Löhler, J., Friel, J., Scheller, M., Horak, I., Stocking, C. J. Exp. Med. (2002) [Pubmed]
  32. Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells. Rambaldi, A., Wakamiya, N., Vellenga, E., Horiguchi, J., Warren, M.K., Kufe, D., Griffin, J.D. J. Clin. Invest. (1988) [Pubmed]
  33. Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32D. Migliaccio, G., Migliaccio, A.R., Kreider, B.L., Rovera, G., Adamson, J.W. J. Cell Biol. (1989) [Pubmed]
  34. C/EBPalpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Wang, X., Scott, E., Sawyers, C.L., Friedman, A.D. Blood (1999) [Pubmed]
  35. Identification in chicken macrophages of a set of proteins related to, but distinct from, the chicken cellular c-ets-encoded protein p54c-ets. Ghysdael, J., Gegonne, A., Pognonec, P., Boulukos, K., Leprince, D., Dernis, D., Lagrou, C., Stehelin, D. EMBO J. (1986) [Pubmed]
  36. Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins. Saito, H., Hatake, K., Dvorak, A.M., Leiferman, K.M., Donnenberg, A.D., Arai, N., Ishizaka, K., Ishizaka, T. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  37. Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation. Borregaard, N., Sehested, M., Nielsen, B.S., Sengeløv, H., Kjeldsen, L. Blood (1995) [Pubmed]
  38. A comparison of surface marker analysis and FAB classification in acute myeloid leukemia. van der Reijden, H.J., van Rhenen, D.J., Lansdorp, P.M., van't Veer, M.B., Langenhuijsen, M.M., Engelfriet, C.P., von dem Borne, A.E. Blood (1983) [Pubmed]
  39. Identification of a 3'-->5'-exonuclease that removes cytosine arabinoside monophosphate from 3' termini of DNA. Perrino, F.W., Miller, H., Ealey, K.A. J. Biol. Chem. (1994) [Pubmed]
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