High impact information on Spink4

• However, in small intestine activation of the Mpgc60 gene occurred earlier than in the large intestine [1].
• In situ hybridization analysis demonstrated strong Mpgc60 expression in Paneth cells and in a subset of goblet cells in the differentiated gut [1].
• Apart from the intestinal tract, MPGC60 mRNA was also detectable in the mesenchyme surrounding the uterine epithelium and in endothelia of some blood vessels [1].
• However, in contrast to the situation observed in pig, no Mpgc60 expression was detectable by Northern, in situ and reverse transcriptase polymerase chain reaction (RT-PCR) analysis in cells of the immune system, that is, in monocytes, macrophages, peripheral blood and in spleen [1].

Anatomical context of Spink4

• During postnatal differentiation of the gut, a strong increase in Mpgc60 expression was detected in both small and large intestine [1].

Analytical, diagnostic and therapeutic context of Spink4

• Molecular cloning and characterization of murine Mpgc60, a gene predominantly expressed in the intestinal tract [1].

References