The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Stag2  -  stromal antigen 2

Mus musculus

Synonyms: 9230105L23Rik, B230112I07Rik, Cohesin subunit SA-2, SA-2, SAP2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Stag2

  • This result shows that immune protection against systemic candidiasis in mice immunized with Sap2 is antibody-mediated [1].

High impact information on Stag2

  • In this study we assessed the potential of vaccination with C. albicans secreted aspartic proteinase 2 (Sap2) in preventing systemic candidiasis in BALB/c mice [1].
  • Captopril significantly reduced the proportion of high proliferative potential colony-forming cells (HPP-CFC-1) in S-phase, whereas it had no effect on the proportion of SA2 leukaemic colony-forming cells in S-phase [2].
  • Regenerating bone marrow cells obtained from mice given one injection of cytosine arabinoside (100 mg/kg) as well as SA2 myeloid leukaemia cells were incubated in vitro for 24 h with 10-6 M captopril [2].
  • In human fusions the SPAZ4 and SA2 lines showed a heterokaryon frequency nearly as good as mouse myelomas, whereas U-266 yielded no growing hybridomas despite 20% heterokaryon frequency [3].
  • Four mouse myelomas commonly used for cell fusions (X63.Ag8.653, SP2/0, NS1, P3U1), 3 human myeloma-like cell lines (ARH77, U-266, GM1500) and 3 human x mouse hybridomas (SPAZ4, SA2, SA3) were compared for their heterokaryon formation and successful hybridoma growth after cell fusion with polyethylene glycol [3].

Analytical, diagnostic and therapeutic context of Stag2

  • Intradermal injection of highly purified native Sap2 protein incorporated in alum adjuvant provided efficient immune protection, as indicated by a 20-fold decrease in the colonization of kidneys [1].
  • With reverse transcriptase-polymerase chain reaction (RT-PCR), mRNA for SAP 4 and SAP6 were detected in the stomach of all mice, whereas SAP2, SAP3 and SAP5 mRNA were detected not in all animals and SAP1 mRNA was not detectable [4].


  1. Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2. Vilanova, M., Teixeira, L., Caramalho, I., Torrado, E., Marques, A., Madureira, P., Ribeiro, A., Ferreira, P., Gama, M., Demengeot, J. Immunology (2004) [Pubmed]
  2. Captopril inhibits in vitro and in vivo the proliferation of primitive haematopoietic cells induced into cell cycle by cytotoxic drug administration or irradiation but has no effect on myeloid leukaemia cell proliferation. Chisi, J.E., Briscoe, C.V., Ezan, E., Genet, R., Riches, A.C., Wdzieczak-Bakala, J. Br. J. Haematol. (2000) [Pubmed]
  3. Estimation of heterokaryon formation and hybridoma growth in murine and human cell fusions. Alkan, S.S., Mestel, F., Jiricka, J., Blaser, K. Hybridoma (1987) [Pubmed]
  4. Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice. Kretschmar, M., Felk, A., Staib, P., Schaller, M., Hess, D., Callapina, M., Morschhäuser, J., Schäfer, W., Korting, H.C., Hof, H., Hube, B., Nichterlein, T. Microb. Pathog. (2002) [Pubmed]
WikiGenes - Universities