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Gene Review

Klk6  -  kallikrein related-peptidase 6

Mus musculus

Synonyms: AI849898, BSP, Bssp, Klk29, MSP, ...
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Disease relevance of Klk6


Psychiatry related information on Klk6


High impact information on Klk6


Biological context of Klk6


Anatomical context of Klk6


Associations of Klk6 with chemical compounds

  • The endogenous inhibitor (MHPI) is a glycoprotein (110.0 kDa) that efficiently blocks the protease M-dependent proteolysis of myofibrillar proteins in a dose-dependent way, as shown by electrophoretic analysis and synthetic substrates assays [10].
  • While K(+) increased protease M activity, the presence of Ca(2+) did not show any effect [11].
  • Endogenous inhibitor and various compounds effects on protease M activity were also quantified by trichloroacetic acid soluble products formation, using radiolabeled myofibrils [11].

Analytical, diagnostic and therapeutic context of Klk6


  1. Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease. Christophi, G.P., Isackson, P.J., Blaber, S., Blaber, M., Rodriguez, M., Scarisbrick, I.A. J. Neurochem. (2004) [Pubmed]
  2. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Chan, S.L., Culmsee, C., Haughey, N., Klapper, W., Mattson, M.P. Neurobiol. Dis. (2002) [Pubmed]
  3. Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis. Terayama, R., Bando, Y., Jiang, Y.P., Mitrovic, B., Yoshida, S. Neurosci. Lett. (2005) [Pubmed]
  4. A novel system for expressing recombinant proteins over a wide temperature range from 4 to 35 degrees C. Nakashima, N., Tamura, T. Biotechnol. Bioeng. (2004) [Pubmed]
  5. Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients. Zarghooni, M., Soosaipillai, A., Grass, L., Scorilas, A., Mirazimi, N., Diamandis, E.P. Clin. Biochem. (2002) [Pubmed]
  6. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Iwata, A., Maruyama, M., Akagi, T., Hashikawa, T., Kanazawa, I., Tsuji, S., Nukina, N. Hum. Mol. Genet. (2003) [Pubmed]
  7. Lack of stimulatory activity of a phytoestrogen-containing soy extract on the growth of breast cancer tumors in mice. Gallo, D., Ferlini, C., Fabrizi, M., Prislei, S., Scambia, G. Carcinogenesis (2006) [Pubmed]
  8. Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord. Terayama, R., Bando, Y., Takahashi, T., Yoshida, S. Glia (2004) [Pubmed]
  9. Protease M/neurosin mRNA is expressed in mature oligodendrocytes. Yamanaka, H., He, X., Matsumoto, K., Shiosaka, S., Yoshida, S. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  10. Myofibril-bound serine protease and its endogenous inhibitor in mouse: extraction, partial characterization and effect on myofibrils. Sangorrín, M.P., Martone, C.B., Sánchez, J.J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2002) [Pubmed]
  11. Identification of a myofibril-bound serine protease and its endogenous inhibitor in mouse skeletal muscle. Sangorrín, M.P., Martone, C.B., Sánchez, J.J. Int. J. Biochem. Cell Biol. (2000) [Pubmed]
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