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Gene Review

Git1  -  G protein-coupled receptor kinase...

Mus musculus

Synonyms: ARF GAP GIT1, ARF GTPase-activating protein GIT1, Cat-1, GRK-interacting protein 1, p95Cat
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High impact information on Git1

  • Cat-1 is tyrosine-phosphorylated in growing NIH 3T3 fibroblasts, and its tyrosine phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis, and increased in the ensuing G(1) phase [1].
  • Cat-1 and Cat-2 both bind to the COOH-terminal region of p85(Cool-1) and p85(Cool-2) but do not bind to p50(Cool-1) [1].
  • However, the pathogenicity was unaltered when the env gene is exchanged with Moloney MuLV, which uses the Cat1 receptor [2].
  • The positively charged nitroxide spin label, 2,2,6,6-tetramethyl-piperidine-N-oxyl-4-trimethylammonium (Cat1), was encapsulated in two types of liposomes, phosphatidylserine/phosphatidylcholine (PS/PC) and phosphatidylserine/distearoylphosphatidylcholine/dipalmitoylphosphatidyl choline (PS/DSPC/DPPC) [3].
  • PS/PC liposomes interact predominantely with the plasma membrane of TB cells and release Cat1 continuously, whereas the majority of PS/DSPC/DPPC liposomes are taken into the cells intact via endocytosis [3].

Biological context of Git1

  • In order to avoid the complication of reduction of nitroxides in biological media during oxygen measurements, liposomes containing a water-soluble nitroxide, 2,2,6,6-tetramethyl-piperidine-N-oxyl-4-trimethylammonium (Cat1), were used in studies of oxygen consumption by thymus-bone-marrow cells [4].
  • Measurements of cellular respiration using Cat1 contained in liposomes agreed well with the results obtained using free Cat1 [4].


  1. A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. Bagrodia, S., Bailey, D., Lenard, Z., Hart, M., Guan, J.L., Premont, R.T., Taylor, S.J., Cerione, R.A. J. Biol. Chem. (1999) [Pubmed]
  2. Importance of Receptor Usage, Fli1 Activation, and Mouse Strain for the Stem Cell Specificity of 10A1 Murine Leukemia Virus Leukemogenicity. Rodenburg, M., Fischer, M., Engelmann, A., Harbers, S.O., Ziegler, M., L??hler, J., Stocking, C. J. Virol. (2007) [Pubmed]
  3. Delivery of nitroxide spin label to cultured cells by liposomes. Chan, H.C., Magin, R.L., Swartz, H.M. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1988) [Pubmed]
  4. Oximetry in cells and tissues using a nitroxide-liposome system. Chan, H.C., Glockner, J.F., Swartz, H.M. Biochim. Biophys. Acta (1989) [Pubmed]
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