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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Respiration

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Disease relevance of Cell Respiration


High impact information on Cell Respiration


Chemical compound and disease context of Cell Respiration

  • So it appears that the increased loss of oxypurines in HPI is caused by the impact of hypoxia, probably owing to be compromised cellular respiration with a subsequent general displacement of the purine metabolism in the catabolic direction [11].
  • Recently we showed that J1 (L-melphalanyl-p-L-fluorophenylalanine ethyl ester), an alkylating nitrogen mustard-containing dipeptide, exhibited strong cytotoxic activity in fresh human tumor samples in addition to rapid and pronounced inhibition of macromolecular syntheses and cellular respiration in the human tumor lymphoma cell line U-937 GTB [12].
  • During acute (< 30 min) hypoxia, cellular respiration is independent of the O2 concentration as long as PO2 remains above a critical value (5-10 Torr) [13].
  • Lonidamine, a substituted indazole carboxylic acid that inhibits cellular respiration, was given in an escalating oral schedule to 20 evaluable patients with measurable extensive small cell carcinoma of the lung [14].

Biological context of Cell Respiration


Anatomical context of Cell Respiration


Associations of Cell Respiration with chemical compounds


Gene context of Cell Respiration


Analytical, diagnostic and therapeutic context of Cell Respiration


  1. Real-time measurements of dissolved oxygen inside live cells by organically modified silicate fluorescent nanosensors. Koo, Y.E., Cao, Y., Kopelman, R., Koo, S.M., Brasuel, M., Philbert, M.A. Anal. Chem. (2004) [Pubmed]
  2. Effects of glucose, anoxia, and adriamycin on the chemiluminescence of Ehrlich Ascites cells. Cheng, B., Williams, M., Chance, B. FEBS Lett. (1983) [Pubmed]
  3. Further characterization of the expression of SOS functions in recA430 mutants of Escherichia coli. Barbé, J., Guerrero, R., Villaverde, A. Mutat. Res. (1983) [Pubmed]
  4. The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Laaksonen, R., Jokelainen, K., Laakso, J., Sahi, T., Harkonen, M., Tikkanen, M.J., Himberg, J.J. Am. J. Cardiol. (1996) [Pubmed]
  5. Expression of recA-gene dependent SOS functions in Salmonella typhimurium. Guerrero, R., Barbé, J. Antonie Van Leeuwenhoek (1982) [Pubmed]
  6. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Kraytsberg, Y., Kudryavtseva, E., McKee, A.C., Geula, C., Kowall, N.W., Khrapko, K. Nat. Genet. (2006) [Pubmed]
  7. Reduction of cytochrome c oxidase by a second electron leads to proton translocation. Ruitenberg, M., Kannt, A., Bamberg, E., Fendler, K., Michel, H. Nature (2002) [Pubmed]
  8. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Fujita, T., Toda, K., Karimova, A., Yan, S.F., Naka, Y., Yet, S.F., Pinsky, D.J. Nat. Med. (2001) [Pubmed]
  9. Mice without myoglobin. Garry, D.J., Ordway, G.A., Lorenz, J.N., Radford, N.B., Chin, E.R., Grange, R.W., Bassel-Duby, R., Williams, R.S. Nature (1998) [Pubmed]
  10. Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli. Pacelli, R., Wink, D.A., Cook, J.A., Krishna, M.C., DeGraff, W., Friedman, N., Tsokos, M., Samuni, A., Mitchell, J.B. J. Exp. Med. (1995) [Pubmed]
  11. Urinary loss of oxypurines in hypoxic premature neonates. Jensen, M.H., Brinkløv, M.M., Lillquist, K. Biol. Neonate (1980) [Pubmed]
  12. Structure-activity relationship for alkylating dipeptide nitrogen mustard derivatives. Gullbo, J., Tullberg, M., Våbenø, J., Ehrsson, H., Lewensohn, R., Nygren, P., Larsson, R., Luthman, K. Oncol. Res. (2003) [Pubmed]
  13. Inhibition of cytochrome-c oxidase activity during prolonged hypoxia. Chandel, N., Budinger, G.R., Kemp, R.A., Schumacker, P.T. Am. J. Physiol. (1995) [Pubmed]
  14. Phase II study of lonidamine in patients with small cell carcinoma of the lung. Murray, N., Shah, A., Band, P. Cancer treatment reports. (1987) [Pubmed]
  15. Zinc metallothionein imported into liver mitochondria modulates respiration. Ye, B., Maret, W., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  16. Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: implications for neurological impairment associated with maple syrup urine disease. Jouvet, P., Rustin, P., Taylor, D.L., Pocock, J.M., Felderhoff-Mueser, U., Mazarakis, N.D., Sarraf, C., Joashi, U., Kozma, M., Greenwood, K., Edwards, A.D., Mehmet, H. Mol. Biol. Cell (2000) [Pubmed]
  17. Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress. Du, L., Zhang, X., Han, Y.Y., Burke, N.A., Kochanek, P.M., Watkins, S.C., Graham, S.H., Carcillo, J.A., Szabó, C., Clark, R.S. J. Biol. Chem. (2003) [Pubmed]
  18. COX8, the structural gene for yeast cytochrome c oxidase subunit VIII. DNA sequence and gene disruption indicate that subunit VIII is required for maximal levels of cellular respiration and is derived from a precursor which is extended at both its NH2 and COOH termini. Patterson, T.E., Poyton, R.O. J. Biol. Chem. (1986) [Pubmed]
  19. Disruption of cellular energy balance by suramin in intact human prostatic carcinoma cells, a likely antiproliferative mechanism. Rago, R., Mitchen, J., Cheng, A.L., Oberley, T., Wilding, G. Cancer Res. (1991) [Pubmed]
  20. Thyroid hormones augment catecholamine-stimulated brown adipose tissue thermogenesis in the ovine fetus. Klein, A.H., Reviczky, A., Padbury, J.F. Endocrinology (1984) [Pubmed]
  21. Mechanism of inhibition of rat liver mitochondrial respiration by oxmetidine, an H2-receptor antagonist. Hoke, G.D., Cheng, H.Y., Mirabelli, C.K., Rush, G.F. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  22. Effect of eugenol on respiration and division in human pulp, mouse fibroblasts, and liver cells in vitro. Hume, W.R. J. Dent. Res. (1984) [Pubmed]
  23. Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum. Vorobjev, I.A., Zorov, D.B. FEBS Lett. (1983) [Pubmed]
  24. Intracellular respiratory dysfunction and cell injury in short-term anoxia of rabbit renal proximal tubules. Takano, T., Soltoff, S.P., Murdaugh, S., Mandel, L.J. J. Clin. Invest. (1985) [Pubmed]
  25. Aspirin induces morphological transformation to the secretory state in isolated rabbit parietal cells. Murthy, U.K., Levine, R.A. Gastroenterology (1991) [Pubmed]
  26. Coordination of nuclear and mitochondrial genome expression during mitochondrial biogenesis in Arabidopsis. Giegé, P., Sweetlove, L.J., Cognat, V., Leaver, C.J. Plant Cell (2005) [Pubmed]
  27. The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process. Tsukihara, T., Shimokata, K., Katayama, Y., Shimada, H., Muramoto, K., Aoyama, H., Mochizuki, M., Shinzawa-Itoh, K., Yamashita, E., Yao, M., Ishimura, Y., Yoshikawa, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  28. The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site. Abramson, J., Riistama, S., Larsson, G., Jasaitis, A., Svensson-Ek, M., Laakkonen, L., Puustinen, A., Iwata, S., Wikström, M. Nat. Struct. Biol. (2000) [Pubmed]
  29. T7 RNA polymerase-dependent expression of COXII in yeast mitochondria. Pinkham, J.L., Dudley, A.M., Mason, T.L. Mol. Cell. Biol. (1994) [Pubmed]
  30. Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Schulz, R., Rassaf, T., Massion, P.B., Kelm, M., Balligand, J.L. Pharmacol. Ther. (2005) [Pubmed]
  31. Mitochondrial fatty acid synthesis and maintenance of respiratory competent mitochondria in yeast. Hiltunen, J.K., Okubo, F., Kursu, V.A., Autio, K.J., Kastaniotis, A.J. Biochem. Soc. Trans. (2005) [Pubmed]
  32. Characterization of the aegA locus of Escherichia coli: control of gene expression in response to anaerobiosis and nitrate. Cavicchioli, R., Kolesnikow, T., Chiang, R.C., Gunsalus, R.P. J. Bacteriol. (1996) [Pubmed]
  33. Uncoupling of protein-3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cells. Guerini, D., Prati, E., Desai, U., Nick, H.P., Flammer, R., Grüninger, S., Cumin, F., Kaleko, M., Connelly, S., Chiesi, M. Eur. J. Biochem. (2002) [Pubmed]
  34. The catalytic cycle of cytochrome c oxidase is not the sum of its two halves. Bloch, D., Belevich, I., Jasaitis, A., Ribacka, C., Puustinen, A., Verkhovsky, M.I., Wikström, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  35. Effects of cisplatin on mitochondrial function in Jurkat cells. Tacka, K.A., Dabrowiak, J.C., Goodisman, J., Penefsky, H.S., Souid, A.K. Chem. Res. Toxicol. (2004) [Pubmed]
  36. Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia. Pittner, A., Nalos, M., Asfar, P., Yang, Y., Ince, C., Georgieff, M., Brückner, U.B., Radermacher, P., Fröba, G. Intensive care medicine. (2003) [Pubmed]
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