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Gene Review

Thbs3  -  thrombospondin 3

Mus musculus

Synonyms: TSP3, Thbs-3, Thrombospondin-3, Tsp3
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Disease relevance of Thbs3


High impact information on Thbs3


Biological context of Thbs3

  • Thus, despite the potential for common regulatory mechanisms, the available evidence indicates that the Mtx minimal promoter does not significantly affect Thbs3 gene expression [4].
  • The gene duplication that produced the thrombospondin-1 and -2 branches of the family is predicted to have occurred 583 million years ago, whereas the gene duplication that produced the thrombospondin-3 and -4 branches of the family is predicted to have occurred 644 million years ago [5].
  • The gene is contiguous to thrombospondin 3 (THBS3) and to the pseudogene for glucocerebrosidase (psGBA), but it transcribed in a direction opposite to the latter two genes [6].

Associations of Thbs3 with chemical compounds


  1. A far upstream, cell type-specific enhancer of the mouse thrombospondin 3 gene is located within intron 6 of the adjacent metaxin gene. Collins, M., Rojnuckarin, P., Zhu, Y.H., Bornstein, P. J. Biol. Chem. (1998) [Pubmed]
  2. Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease. Bornstein, P., McKinney, C.E., LaMarca, M.E., Winfield, S., Shingu, T., Devarayalu, S., Vos, H.L., Ginns, E.I. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Hankenson, K.D., Hormuzdi, S.G., Meganck, J.A., Bornstein, P. Mol. Cell. Biol. (2005) [Pubmed]
  4. SP1-binding elements, within the common metaxin-thrombospondin 3 intergenic region, participate in the regulation of the metaxin gene. Collins, M., Bornstein, P. Nucleic Acids Res. (1996) [Pubmed]
  5. The evolution of the thrombospondin gene family. Lawler, J., Duquette, M., Urry, L., McHenry, K., Smith, T.F. J. Mol. Evol. (1993) [Pubmed]
  6. Structure and organization of the human metaxin gene (MTX) and pseudogene. Long, G.L., Winfield, S., Adolph, K.W., Ginns, E.I., Bornstein, P. Genomics (1996) [Pubmed]
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