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Gene Review

THBS3  -  thrombospondin 3

Homo sapiens

Synonyms: TSP3, Thrombospondin-3
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Disease relevance of THBS3

  • RESULTS: THBS3, SPARC and SPP1 were identified as genes differentially expressed in osteosarcoma [1].
  • In particular, THBS3 was expressed at significantly high levels (p = 0.0001) in biopsies from patients with metastasis at diagnosis, which is a predictor of worse overall survival, event-free survival and relapse free survival at diagnosis [1].

High impact information on THBS3


Biological context of THBS3

  • Analysis of cDNA and genomic sequences showed the THBS3 gene to be composed of 23 exons, 1 more than the number of exons in the previously characterized mouse TSP3 gene [6].
  • The THBS3 and mouse TSP3 genes differ in intron sizes, but exon sequences and sizes and positions of insertion of introns are conserved to a high degree [6].
  • In the human genome, the TSP-1, TSP-3, TSP-4 and TSP-5 genes lie within paralogous regions that provide insight into the ancestral genomic context of vertebrate TSPs [7].
  • Primer extension analyses using 5' upstream primers now identify an additional cluster of tsp between -1035 and -1340 base pairs (tsp3) [4].
  • Thus, MTX and THBS3 share a common promoter region and are transcribed convergently, whereas MTX and psGBA are transcribed convergently and have closed apposed polyadenylation sites [8].

Anatomical context of THBS3


Associations of THBS3 with chemical compounds

  • Binding assays with 45Ca2+ as ligand and immobilized TSP1, TSP2 and TSP3 demonstrated that all three TSPs are calcium-binding proteins [12].
  • In addition to these type III repeats, four type II (EGF-like) repeats and NH2- and COOH-terminal domains are present in thrombospondin 3 [6].

Other interactions of THBS3


Analytical, diagnostic and therapeutic context of THBS3


  1. Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. Dalla-Torre, C.A., Yoshimoto, M., Lee, C.H., Joshua, A.M., de Toledo, S.R., Petrilli, A.S., Andrade, J.A., Chilton-MacNeill, S., Zielenska, M., Squire, J.A. BMC Cancer (2006) [Pubmed]
  2. Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. Misenheimer, T.M., Mosher, D.F. J. Biol. Chem. (2005) [Pubmed]
  3. Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues. Qabar, A., Derick, L., Lawler, J., Dixit, V. J. Biol. Chem. (1995) [Pubmed]
  4. Transcription of the rat alpha 1B adrenergic receptor gene in liver is controlled by three promoters. Gao, B., Kunos, G. J. Biol. Chem. (1994) [Pubmed]
  5. Thrombospondin 3 is a developmentally regulated heparin binding protein. Qabar, A.N., Lin, Z., Wolf, F.W., O'Shea, K.S., Lawler, J., Dixit, V.M. J. Biol. Chem. (1994) [Pubmed]
  6. Structure and organization of the human thrombospondin 3 gene (THBS3). Adolph, K.W., Long, G.L., Winfield, S., Ginns, E.I., Bornstein, P. Genomics (1995) [Pubmed]
  7. Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation. McKenzie, P., Chadalavada, S.C., Bohrer, J., Adams, J.C. BMC Evol. Biol. (2006) [Pubmed]
  8. Structure and organization of the human metaxin gene (MTX) and pseudogene. Long, G.L., Winfield, S., Adolph, K.W., Ginns, E.I., Bornstein, P. Genomics (1996) [Pubmed]
  9. Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues. Adolph, K.W. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  10. Keratocyte matrix interactions and thrombospondin 2. Armstrong, D.J., Hiscott, P., Batterbury, M., Kaye, S. Mol. Vis. (2003) [Pubmed]
  11. In situ localization of thrombospondin-1 and thrombospondin-3 transcripts in the avian embryo. Tucker, R.P., Hagios, C., Chiquet-Ehrismann, R., Lawler, J. Dev. Dyn. (1997) [Pubmed]
  12. Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3. Chen, H., Aeschlimann, D., Nowlen, J., Mosher, D.F. FEBS Lett. (1996) [Pubmed]
  13. The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript. Adolph, K.W., Bornstein, P. Mol. Cell Biol. Res. Commun. (1999) [Pubmed]
  14. Expression of members of the thrombospondin family by human skeletal tissues and cultured cells. Carron, J.A., Bowler, W.B., Wagstaff, S.C., Gallagher, J.A. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  15. Characterization of human and mouse cartilage oligomeric matrix protein. Newton, G., Weremowicz, S., Morton, C.C., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Lawler, J. Genomics (1994) [Pubmed]
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