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Tsix  -  X (inactive)-specific transcript, opposite...

Mus musculus

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High impact information on Tsix


Biological context of Tsix


Anatomical context of Tsix

  • A 65 kb deletion targeted to one of the two Xs in a female ES cell line, and including both the end of the Xist gene and the site of initiation of Tsix, resulted in the exclusive inactivation of the deleted X in differentiated ES cells [7].
  • Expression of Tsix is first detected in blastocysts and is imprinted with only the maternal allele transcribed [8].

Physical interactions of Tsix

  • Here, we test whether Tsix RNA destabilizes Xist RNA [9].

Regulatory relationships of Tsix


Other interactions of Tsix

  • These experiments revealed the intergenic transcription element Xite as an enhancer of Tsix and the repeat element DXPas34 as a component of the bipartite enhancer [5].
  • Critical control sequences in the Xic include the non-coding RNAs Xist and Tsix, and long-range chromatin elements [10].

Analytical, diagnostic and therapeutic context of Tsix


  1. Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Lee, J.T. Nat. Genet. (2002) [Pubmed]
  2. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix. Lee, J.T. Cell (2000) [Pubmed]
  3. Skewing X chromosome choice by modulating sense transcription across the Xist locus. Nesterova, T.B., Johnston, C.M., Appanah, R., Newall, A.E., Godwin, J., Alexiou, M., Brockdorff, N. Genes Dev. (2003) [Pubmed]
  4. Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Ogawa, Y., Lee, J.T. Mol. Cell (2003) [Pubmed]
  5. Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation. Stavropoulos, N., Rowntree, R.K., Lee, J.T. Mol. Cell. Biol. (2005) [Pubmed]
  6. Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Lee, J.T., Lu, N. Cell (1999) [Pubmed]
  7. Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation. Morey, C., Arnaud, D., Avner, P., Clerc, P. Hum. Mol. Genet. (2001) [Pubmed]
  8. Regulation of imprinted X-chromosome inactivation in mice by Tsix. Sado, T., Wang, Z., Sasaki, H., Li, E. Development (2001) [Pubmed]
  9. A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Sun, B.K., Deaton, A.M., Lee, J.T. Mol. Cell (2006) [Pubmed]
  10. Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Bacher, C.P., Guggiari, M., Brors, B., Augui, S., Clerc, P., Avner, P., Eils, R., Heard, E. Nat. Cell Biol. (2006) [Pubmed]
  11. Control of Xist expression for imprinted and random X chromosome inactivation in mice. Matsui, J., Goto, Y., Takagi, N. Hum. Mol. Genet. (2001) [Pubmed]
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