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Gene Review

ITGA11  -  integrin, alpha 11

Homo sapiens

Synonyms: HsT18964, Integrin alpha-11, MSTP018
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Disease relevance of ITGA11


High impact information on ITGA11

  • We previously established that a 3 kb region upstream of the transcription start site of the ITGA11 gene efficiently induced alpha11 transcription in a cell-type specific manner [3].
  • Based on available human chromosome 15-derived sequences and genomic PCR, the complete exon structure of ITGA11, including the proximal promoter, was assembled into 30 exons [4].
  • Furthermore, studies of the promoter region will provide valuable information regarding the molecular mechanisms underlying the cell- and tissue- specific expression pattern of ITGA11 [4].
  • The human ITGA11 gene was localized to bands q22.3-q23 on chromosome 15, and its transcripts were found in a variety of tissues, but predominantly in bone, cartilage, cardiac muscle, and skeletal muscle [5].
  • We observed that the ITGA-11 promoter has binding sites for transcriptional factors regulated by IFNs and the double-stranded RNA dependent protein kinase (PKR) [2].

Anatomical context of ITGA11


Associations of ITGA11 with chemical compounds

  • The aim of this work was to investigate whether integrin alpha 11 (ITGA-11), a novel collagen-binding integrin, is responsive to type I IFN treatment [2].

Analytical, diagnostic and therapeutic context of ITGA11


  1. Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer. Chong, I.W., Chang, M.Y., Chang, H.C., Yu, Y.P., Sheu, C.C., Tsai, J.R., Hung, J.Y., Chou, S.H., Tsai, M.S., Hwang, J.J., Lin, S.R. Oncol. Rep. (2006) [Pubmed]
  2. Integrin alpha 11 is a novel type I interferon stimulated gene. Leomil Coelho, L.F., Mota, B.E., Sales, P.C., Marques, J.T., de Oliveira, J.G., Bonjardim, C.A., Peregrino Ferreira, P.C., Kroon, E.G. Cytokine (2006) [Pubmed]
  3. Tandem Sp1/Sp3 sites together with an Ets-1 site cooperate to mediate alpha11 integrin chain expression in mesenchymal cells. Lu, N., Heuchel, R., Barczyk, M., Zhang, W.M., Gullberg, D. Matrix Biol. (2006) [Pubmed]
  4. Analysis of the human integrin alpha11 gene (ITGA11) and its promoter. Zhang, W.M., Popova, S.N., Bergman, C., Velling, T., Gullberg, M.K., Gullberg, D. Matrix Biol. (2002) [Pubmed]
  5. Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11). Lehnert, K., Ni, J., Leung, E., Gough, S.M., Weaver, A., Yao, W.P., Liu, D., Wang, S.X., Morris, C.M., Krissansen, G.W. Genomics (1999) [Pubmed]
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