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Gene Review

SCMH1  -  sex comb on midleg homolog 1 (Drosophila)

Homo sapiens

Synonyms: Polycomb protein SCMH1, Scml3, Sex comb on midleg homolog 1
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Disease relevance of SCMH1


High impact information on SCMH1

  • Therefore, for the first time, we are able to indicate a functional involvement of Prc1 during the meiotic prophase of male germ cells and a regulatory role of Scmh1 for Prc1, which involves sex chromosomes [2].
  • We have identified the role of Scmh1 in mediating the survival of late pachytene spermatocytes [2].
  • The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34 [3].
  • These data suggest that Scmh1 will have an important role in regulation of homeotic genes in embryogenesis and that the interaction with RAE28/mph1 is important in vivo [1].
  • However, in adults, Scmh1 expression was detected in most tissues, whereas mph1/rae28 expression was restricted to the gonads [1].

Biological context of SCMH1

  • Apoptotic elimination of Scmh1(-/-) spermatocytes is accompanied by the preceding failure of several specific chromatin modifications at the XY body, whereas synapsis of homologous autosomes is not affected [2].

Other interactions of SCMH1

  • The product of the Scmh1 gene, a mammalian homolog of Drosophila Sex comb on midleg, is a constituent of the mammalian Polycomb repressive complexes 1 (Prc1) [2].

Analytical, diagnostic and therapeutic context of SCMH1

  • We analyzed the expression of Scmh1 and rae28/mph1 using northern analysis of embryos and adult tissues, and in situ hybridization to embryos [1].


  1. A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro. Tomotsune, D., Takihara, Y., Berger, J., Duhl, D., Joo, S., Kyba, M., Shirai, M., Ohta, H., Matsuda, Y., Honda, B.M., Simon, J., Shimada, K., Brock, H.W., Randazzo, F. Differentiation (1999) [Pubmed]
  2. Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Takada, Y., Isono, K., Shinga, J., Turner, J.M., Kitamura, H., Ohara, O., Watanabe, G., Singh, P.B., Kamijo, T., Jenuwein, T., Burgoyne, P.S., Koseki, H. Development (2007) [Pubmed]
  3. The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. Berger, J., Kurahashi, H., Takihara, Y., Shimada, K., Brock, H.W., Randazzo, F. Gene (1999) [Pubmed]
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