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Gene Review

MAST2  -  microtubule associated serine/threonine...

Homo sapiens

Synonyms: KIAA0807, MAST205, MTSSK, Microtubule-associated serine/threonine-protein kinase 2
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High impact information on MAST2

  • Binding of MAST205 to microtubules requires interaction with other MAPs, since it does not bind to MAP-free tubulin [1].
  • Antibodies affinity purified by using one expression clone recognized a 205-kDa protein, termed MAST205, which colocalizes with the spermatid manchette [1].
  • The MAST205 protein complex may function to link the signal transduction pathway with the organization of manchette microtubules [1].
  • Sequencing of full-length cDNA clones encoding MAST205 revealed it to be a novel serine/threonine kinase with a catalytic domain related to those of the A and C families [1].
  • RNA interference targeting MAST205, a 205-kDa serine/threonine kinase, and transfection of dominant negative MAST205 mutants also mimic this type II macrophage phenotype [2].

Biological context of MAST2

  • The objective of this study was to further delineate the role of MAST205 in mammalian spermiogenesis [3].
  • The domain required for degradation of MAST205 after Fcgamma receptor activation resides within the N-terminal 261 residues, and degradation is triggered by protein kinase C isoform phosphorylation of Ser/Thr residues [2].

Anatomical context of MAST2

  • We recently cloned a novel 205-kDa manchette microtubule-associated serine/threonine protein kinase (MAST205) from mouse testis [3].
  • Taken together, these results indicate that the MAST205 complex functions in spermatid maturation in mammals [3].
  • While MAST205 RNA levels were similar in pachytene spermatocytes, round spermatids, and residual bodies, MAST205 protein could be detected only in round spermatids and residual bodies [3].
  • Multiple heterologous protein species were seen in immunoprecipitates from 35S-labeled mouse seminiferous tubules using an affinity-purified MAST205 antiserum [3].
  • Furthermore, MAST205 protein and the associated kinase activity were not detected in epididymal spermatozoa, indicating that MAST205 protein is either excluded from, or degraded in, the latter cell type [3].


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