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Gene Review

ZNF629  -  zinc finger protein 629

Homo sapiens

Synonyms: KIAA0326, ZNF, ZNF65, Zinc finger protein 629, Zinc finger protein 65
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High impact information on ZNF629

  • KRAB-ZNF proteins, in which a potent repressor domain is attached to a tandem array of DNA-binding zinc-finger motifs, are specific to tetrapod vertebrates and represent the largest class of ZNF proteins in mammals [1].
  • High-resolution mapping on human chromosome 19 revealed that CBX1 coats large domains 0.1-4 Mb in size, which coincide with the position of KRAB-ZNF gene clusters [2].
  • Mammalian genomes carry hundreds of Krüppel-type zinc finger (ZNF) genes, most of which reside in familial clusters [3].
  • We cloned the cDNA of a novel Kruppel-type zinc finger (ZNF) gene, ZK7, from a cDNA library constructed from the human leukemia cell line CMK86 after incubation with VEGF [4].
  • This cDNA encoded a protein of 289 amino acids, which contained a Kruppel-associated box A-box domain at the NH2 terminus and seven ZNF motifs at the COOH terminus [4].

Biological context of ZNF629

  • Krüppel-type zinc finger (ZNF) motifs are prevalent components of transcription factor proteins in all eukaryotes [1].
  • In this study we have localized human PEG3 approximately 2 Mb proximal of the telomere of chromosome 19q, within a region known to carry large numbers of tandemly clustered Krüppel-type zinc finger-containing (ZNF) genes [5].
  • Two related zinc finger (ZNF) gene clusters from the pericentromeric region of human chromosome 10, defined by cDNAs of the KOX series, have been cloned in yeast artificial chromosomes (YACs) [6].
  • Comparative studies of the human and pig sequences of the class I-containing segments indeed revealed the presence within the human HSR1-ZNF segment of relics of a human class I fossil gene which appeared to be orthologous to the 5' moiety of the SLA-11 pseudogene [7].
  • Several lines of evidence now suggest that many of the zinc-finger-containing (ZNF) genes in the human genome are arranged in clusters [8].

Analytical, diagnostic and therapeutic context of ZNF629

  • Gel mobility shift assays of this cis-regulatory region revealed a high complexity of the basal promoter with a cooperative binding of several transcription factors, like Sp and ZNF family members [9].


  1. A comprehensive catalog of human KRAB-associated zinc finger genes: Insights into the evolutionary history of a large family of transcriptional repressors. Huntley, S., Baggott, D.M., Hamilton, A.T., Tran-Gyamfi, M., Yang, S., Kim, J., Gordon, L., Branscomb, E., Stubbs, L. Genome Res. (2006) [Pubmed]
  2. Human heterochromatin proteins form large domains containing KRAB-ZNF genes. Vogel, M.J., Guelen, L., de Wit, E., Hupkes, D.P., Lod??n, M., Talhout, W., Feenstra, M., Abbas, B., Classen, A.K., van Steensel, B. Genome Res. (2006) [Pubmed]
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon, M., Hamilton, A.T., Gordon, L., Branscomb, E., Stubbs, L. Genome Res. (2003) [Pubmed]
  4. ZK7, a novel zinc finger gene, is induced by vascular endothelial growth factor and inhibits apoptotic death in hematopoietic cells. Kuramoto, K., Uesaka, T., Kimura, A., Kobayashi, M., Watanabe, H., Katoh, O. Cancer Res. (2000) [Pubmed]
  5. The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. Kim, J., Ashworth, L., Branscomb, E., Stubbs, L. Genome Res. (1997) [Pubmed]
  6. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe, A., Liu, L., Moore, J.K., Leversha, M.A., Jackson, M.S., Papi, L., Ferguson-Smith, M.A., Thiesen, H.J., Ponder, B.A. Nucleic Acids Res. (1993) [Pubmed]
  7. The phylogenetic history of the MHC class I gene families in pig, including a fossil gene predating mammalian radiation. Renard, C., Chardon, P., Vaiman, M. J. Mol. Evol. (2003) [Pubmed]
  8. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. Shannon, M., Ashworth, L.K., Mucenski, M.L., Lamerdin, J.E., Branscomb, E., Stubbs, L. Genomics (1996) [Pubmed]
  9. Complex regulation of human neuronal nitric-oxide synthase exon 1c gene transcription. Essential role of Sp and ZNF family members of transcription factors. Saur, D., Seidler, B., Paehge, H., Schusdziarra, V., Allescher, H.D. J. Biol. Chem. (2002) [Pubmed]
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