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RAB38  -  RAB38, member RAS oncogene family

Homo sapiens

Synonyms: Melanoma antigen NY-MEL-1, NY-MEL-1, Ras-related protein Rab-38, rrGTPbp
 
 
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Disease relevance of RAB38

  • Consistent with this lineage specificity, rab38 mRNA is expressed in 80-90% of melanoma (17 of 19), but rarely in nonmelanocytic malignancies (1 of 16) [1].
 

High impact information on RAB38

  • This work identifies a key role for the Rab38/Rab32 subfamily of Rab proteins in the biogenesis of melanosomes and potentially other lysosome-related organelles [2].
  • Amutation in the small GTPase Rab38 gives rise to the mouse coat color phenotype "chocolate" (cht), implicating Rab38 in the regulation of melanogenesis [2].
  • These observations, and the fact that green fluorescent protein-tagged RAB38 colocalizes with end-stage melanosomes in wild-type melanocytes, suggest that RAB38 plays a role in the sorting of TYRP1 [3].
  • Examination of similarities in human gene expression patterns by using microarray analysis reveals that RAB38, a small GTP binding protein, demonstrates a similar expression profile to melanocytic genes [3].
  • In the present study, a melanoma library was screened by SEREX (serological analysis of cDNA expression libraries), and 43 genes were isolated, 2 of which, NY-MEL-1 and NY-MEL-3, encode novel gene products with differential tissue expression [1].
 

Biological context of RAB38

 

Anatomical context of RAB38

  • Recently two genes, RAB38 and RAB7, were reported to play an important role in melanogenesis in the melanocyte, suggesting that these two genes could be good candidates for new OCA loci [6].
  • Mutation of melanosome protein RAB38 in chocolate mice [3].
  • Applying fluorescent HLA-A2/RAB38/NY-MEL-1(50-58) multimeric constructs, we were able to document a spontaneously developed memory/effector CD8 T cell response against this peptide in a melanoma patient [5].
  • Accordingly, monoclonal RAB38/NY-MEL-1(50-58)-specific T cell populations were capable of specifically recognizing HLA-A2(+) melanoma cell lines expressing RAB38/NY-MEL-1 [5].
  • These results suggest that this novel rab small G protein (Rab38) mediates vesicular transport in terminal airway epithelium [7].
 

Other interactions of RAB38

  • Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA [6].
  • The identified peptide RAB38/NY-MEL-1(50-58) exhibited a marked response in ELISPOT assays after in vitro sensitization of CD8 T cells from HLA-A *0201(+) melanoma patients [5].

References

  1. Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. Jäger, D., Stockert, E., Jäger, E., Güre, A.O., Scanlan, M.J., Knuth, A., Old, L.J., Chen, Y.T. Cancer Res. (2000) [Pubmed]
  2. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. Wasmeier, C., Romao, M., Plowright, L., Bennett, D.C., Raposo, G., Seabra, M.C. J. Cell Biol. (2006) [Pubmed]
  3. Mutation of melanosome protein RAB38 in chocolate mice. Loftus, S.K., Larson, D.M., Baxter, L.L., Antonellis, A., Chen, Y., Wu, X., Jiang, Y., Bittner, M., Hammer, J.A., Pavan, W.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Melanocyte differentiation antigen RAB38/NY-MEL-1 induces frequent antibody responses exclusively in melanoma patients. Zippelius, A., Gati, A., Bartnick, T., Walton, S., Odermatt, B., Jaeger, E., Dummer, R., Urosevic, M., Filonenko, V., Osanai, K., Moch, H., Chen, Y.T., Old, L.J., Knuth, A., Jaeger, D. Cancer Immunol. Immunother. (2007) [Pubmed]
  5. Spontaneous CD8 T Cell Responses against the Melanocyte Differentiation Antigen RAB38/NY-MEL-1 in Melanoma Patients. Walton, S.M., Gerlinger, M., de la Rosa, O., Nuber, N., Knights, A., Gati, A., Laumer, M., Strauss, L., Exner, C., Sch??fer, N., Urosevic, M., Dummer, R., Tiercy, J.M., Mackensen, A., Jaeger, E., L??vy, F., Knuth, A., J??ger, D., Zippelius, A. J. Immunol. (2006) [Pubmed]
  6. Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA. Suzuki, T., Miyamura, Y., Inagaki, K., Tomita, Y. J. Dermatol. Sci. (2003) [Pubmed]
  7. Expression and localization of a novel Rab small G protein (Rab38) in the rat lung. Osanai, K., Iguchi, M., Takahashi, K., Nambu, Y., Sakuma, T., Toga, H., Ohya, N., Shimizu, H., Fisher, J.H., Voelker, D.R. Am. J. Pathol. (2001) [Pubmed]
 
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