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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

EML2  -  echinoderm microtubule associated protein...

Homo sapiens

Synonyms: ELP70, EMAP-2, EMAP2, EMAPL2, Echinoderm microtubule-associated protein-like 2, ...
 
 
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Disease relevance of EML2

  • RESULTS: EMAP-2 is transcribed and translated by the placenta troughout pregnancy and in preeclampsia and can be detected in the plasma of nonpregnant and pregnant individuals [1].
 

High impact information on EML2

 

Analytical, diagnostic and therapeutic context of EML2

  • Northern blot analysis indicates that HuEMAP-1, and HuEMAP-2 are expressed in different human tissues [3].
  • Levels of circulating EMAP-2 protein were measured in the blood of nonpregnant, normal pregnant, and preeclamptic individuals using a specific enzyme-linked immunoabsorbent assay and the molecular forms present assessed by Western blotting [1].
  • METHODS: Expression of EMAP-2 in the placenta was investigated using reverse transcriptase-polymerase chain reaction to detect mRNA, and immunohistochemistry with an EMAP-2-specific polyclonal antiserum was carried out to detect protein [1].
  • Recombinant EMAP-2 (rEMAP-2) was isolated by thrombin cleavage of the fusion protein, followed by affinity chromatography. rEMAP-2 retained biological activity, which was blocked by polyclonal antibodies raised against GST-EMAP-2 [4].
  • We generated the full-length human cDNA sequences of EMAP-2 and its putative precursor pro-EMAP-2 as PCR products [4].

References

  1. Endothelial monocyte-activating polypeptide-2 is increased in pregnancy but is not further increased in preeclampsia. Wellings, R.P., Lash, G.E., Murray, J.C., Tas, M., Ward, W., Trew, A.J., Baker, P.N. J. Soc. Gynecol. Investig. (1999) [Pubmed]
  2. The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus. Eichenmuller, B., Everley, P., Palange, J., Lepley, D., Suprenant, K.A. J. Biol. Chem. (2002) [Pubmed]
  3. Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2). Lepley, D.M., Palange, J.M., Suprenant, K.A. Gene (1999) [Pubmed]
  4. Cloning and expression of human endothelial-monocyte-activating polypeptide 2 (EMAP-2) and identification of its putative precursor. Tas, M.P., Houghton, J., Jakobsen, A.M., Tolmachova, T., Carmichael, J., Murray, J.C. Cytokine (1997) [Pubmed]
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