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Gene Review

EML1  -  echinoderm microtubule associated protein...

Homo sapiens

Synonyms: ELP79, EMAP, EMAP-1, EMAP1, EMAPL, ...
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Disease relevance of EML1

  • Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32) [1].
  • Multipoint analysis indicates that the canine disease gene lies in an interval between the echinoderm microtubule-associated, protein-like 1 ( EML1) gene and the telomere [2].
  • Isolation of a novel human homologue of the gene coding for echinoderm microtubule-associated protein (EMAP) from the Usher syndrome type 1a locus at 14q32 [3].
  • To carry out these experiments, we constructed a recombinant baculovirus that expressed the full-length 77-kD EMAP, an abundant MAP that localizes to the mitotic spindle of cleavage-stage sea urchin embryos and to the interphase array of microtubules in adult coelomocytes [4].

High impact information on EML1

  • In this report, we show that the echinoderm microtubule (MT)-associated protein (EMAP) and related EMAP-like proteins (ELPs) share a similar domain organization with a highly conserved hydrophobic ELP (HELP) domain and a large tryptophan-aspartic acid (WD) repeat domain [5].
  • At all stages of the cell cycle, a 33 kDa polypeptide copurifies with the 77 kDa EMAP, regardless of phosphorylation state [6].
  • As the embryo enters mitosis, EMAP phosphorylation increases, and as the embryo exits mitosis, phosphorylation decreases [6].
  • In the unfertilized egg, EMAP is constitutively phosphorylated on at least five serine residues [6].
  • We subsequently stabile-transfected this cell line with a retroviral construct containing the EMAP gene [7].

Biological context of EML1

  • The nucleotide sequence of the cDNA encodes a protein of 717 amino acids in length, showing a high level of homology to the Echinoderm 77-kDa microtubule-associated protein (EMAP) [3].
  • One of these, HuEMAP-1, is identified as the candidate gene for the Usher syndrome 1 a locus (Genomics 43:104-106, 1997) [8].
  • Identification of rat EMAP, a delta-glutamate receptor binding protein [9].
  • Cell cycle-dependent phosphorylation of the 77 kDa echinoderm microtubule-associated protein (EMAP) in vivo and association with the p34cdc2 kinase [6].
  • EMAP localizes to the mitotic spindle as well as the interphase microtubule array and is a likely target for a cell cycle-activated kinase [6].

Anatomical context of EML1


Associations of EML1 with chemical compounds

  • As this is not the case with high O2 in an EMA film, the latter can be assumed as a promising configuration for respiring fresh produce, combining the beneficial effect of high O2 and EMAP [14].

Other interactions of EML1


Analytical, diagnostic and therapeutic context of EML1


  1. Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32). De Keersmaecker, K., Graux, C., Odero, M.D., Mentens, N., Somers, R., Maertens, J., Wlodarska, I., Vandenberghe, P., Hagemeijer, A., Marynen, P., Cools, J. Blood (2005) [Pubmed]
  2. Canine Imerslund-Gräsbeck syndrome maps to a region orthologous to HSA14q. He, Q., Fyfe, J.C., Schäffer, A.A., Kilkenney, A., Werner, P., Kirkness, E.F., Henthorn, P.S. Mamm. Genome (2003) [Pubmed]
  3. Isolation of a novel human homologue of the gene coding for echinoderm microtubule-associated protein (EMAP) from the Usher syndrome type 1a locus at 14q32. Eudy, J.D., Ma-Edmonds, M., Yao, S.F., Talmadge, C.B., Kelley, P.M., Weston, M.D., Kimberling, W.J., Sumegi, J. Genomics (1997) [Pubmed]
  4. Overexpression of the 77-kD echinoderm microtubule-associated protein (EMAP), a WD-40 repeat protein, in baculovirus-infected Sf9 cells. Daggett, M.A., Li, Q., Weaver, R.F., Suprenant, K.A. Cell Motil. Cytoskeleton (1998) [Pubmed]
  5. The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus. Eichenmuller, B., Everley, P., Palange, J., Lepley, D., Suprenant, K.A. J. Biol. Chem. (2002) [Pubmed]
  6. Cell cycle-dependent phosphorylation of the 77 kDa echinoderm microtubule-associated protein (EMAP) in vivo and association with the p34cdc2 kinase. Brisch, E., Daggett, M.A., Suprenant, K.A. J. Cell. Sci. (1996) [Pubmed]
  7. Improved antitumor response to isolated limb perfusion with tumor necrosis factor after upregulation of endothelial monocyte-activating polypeptide II in soft tissue sarcoma. Lans, T.E., ten Hagen, T.L., van Horssen, R., Wu, P.C., van Tiel, S.T., Libutti, S.K., Alexander, H.R., Eggermont, A.M. Ann. Surg. Oncol. (2002) [Pubmed]
  8. Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2). Lepley, D.M., Palange, J.M., Suprenant, K.A. Gene (1999) [Pubmed]
  9. Identification of rat EMAP, a delta-glutamate receptor binding protein. Ly, C.D., Roche, K.W., Lee, H.K., Wenthold, R.J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  10. Saturable binding of the echinoderm microtubule-associated protein (EMAP) on microtubules, but not filamentous actin or vimentin filaments. Eichenmüller, B., Ahrens, D.P., Li, Q., Suprenant, K.A. Cell Motil. Cytoskeleton (2001) [Pubmed]
  11. Biochemical and immunochemical similarity between erythrocyte membrane aspartic proteinase and cathepsin E. Yamamoto, K., Ueno, E., Uemura, H., Kato, Y. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  12. Human erythrocyte membrane acid proteinase (EMAP): sidedness and relation to cathepsin D. Yamamoto, K., Takeda, M., Yamamoto, H., Tatsumi, M., Kato, Y. J. Biochem. (1985) [Pubmed]
  13. Endothelial monocyte activating polypeptide II (EMAP II) enhances the effect of TNF on tumor-associated vasculature. Kayton, M.L., Libutti, S.K. Current opinion in investigational drugs (London, England : 2000) (2001) [Pubmed]
  14. A combination of high oxygen atmosphere and equilibrium modified atmosphere packaging to improve the keeping quality of red fruits. Van der Steen, C., Jacxsens, L., Devlieghere, F., Debevere, J. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2001) [Pubmed]
  15. The 77-kDa echinoderm microtubule-associated protein (EMAP) shares epitopes with the mammalian brain MAPs, MAP-2 and tau. Li, Q., Callaghan, M., Suprenant, K.A. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  16. Isolation, and catalytic and immunochemical properties of cathepsin D-like acid proteinase from rat erythrocytes. Takeda, M., Ueno, E., Kato, Y., Yamamoto, K. J. Biochem. (1986) [Pubmed]
  17. Lectins isolated from Korean mistletoe (Viscum album coloratum) induce apoptosis in tumor cells. Yoon, T.J., Yoo, Y.C., Kang, T.B., Shimazaki, K., Song, S.K., Lee, K.H., Kim, S.H., Park, C.H., Azuma, I., Kim, J.B. Cancer Lett. (1999) [Pubmed]
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