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Gene Review

sty1  -  MAP kinase Sty1

Schizosaccharomyces pombe 972h-

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Disease relevance of sty1

  • Heterothalic phh1 dsiruptant is phenotypically indistinguishable from wis1 deletion mutant, both displaying the same extent of partial sterility and enhanced sensitivity to a variety of stress [1].

High impact information on sty1

  • A lethal interaction of spc1 and cdc25 mutations shows that Spc1 promotes the onset of mitosis [2].
  • Accordingly, sty1- cells are defective in their response to nutrient limitation, lose viability in stationary phase, and are hypersensitive to osmotic stress, oxidative stress, and UV treatment [3].
  • We find that sty2 is allelic to the wis1 MAP kinase kinase and that delta sty1 and delta wis1 cells are unable to grow in high osmolarity medium [4].
  • This surprising finding is explained by the observation that ctt1+ basal expression is unaffected in atf1 single mutant and spc1 atf1 double mutant cells, suggesting that unphosphorylated Atf1 represses ctt1+ expression in spc1 cells [5].
  • Whereas checkpoint rad mutants fail to arrest division in response to DNA damage, spc1 mutants are defective at resuming cell division after UV exposure [5].

Biological context of sty1

  • In addition, sty1(-) cells are sterile and exhibit a G(2) cell cycle delay, indicating additional roles of Sty1 in meiosis and cell cycle progression [6].
  • It acts at least in part by activating the MAP kinase homologue sty1; loss-of-function sty1 mutants share many phenotypes with wis1 deletion mutants [7].

Associations of sty1 with chemical compounds

  • Expression of the fbp1 gene is negatively regulated by cAMP in response to glucose limitation: induction of fbp1 also requires wis1 and sty1 function [7].
  • The pmp3 null mutant, as well as the spc1 and atf1 mutants, is hypersensitive to the cationic antibiotic hygromycin B [8].
  • In addition, glyoxalase I activity was increased in stress-activated protein kinase-deficient mutants (wis1 and spc1) [9].

Enzymatic interactions of sty1

  • Induction of ste11, a meiosis-specific gene transcription factor, by Stm1 overexpression was enhanced in gpa2-deleted cells but was absent in a deletion mutant of sty1, a key protein kinase that links mitotic control with environmental signals and induces stress-responsive genes [10].

Regulatory relationships of sty1


Other interactions of sty1

  • Overexpression of mkp1(+), like a sty1 mutation, also causes vegetative cells to elongate [12].
  • Expression of the sod1+ gene was induced by oxidative stress and no induction was observed in pap1, prr1 and spc1 mutants [13].


  1. Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast. Kato, T., Okazaki, K., Murakami, H., Stettler, S., Fantes, P.A., Okayama, H. FEBS Lett. (1996) [Pubmed]
  2. Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Shiozaki, K., Russell, P. Nature (1995) [Pubmed]
  3. Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1. Toone, W.M., Kuge, S., Samuels, M., Morgan, B.A., Toda, T., Jones, N. Genes Dev. (1998) [Pubmed]
  4. Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast. Millar, J.B., Buck, V., Wilkinson, M.G. Genes Dev. (1995) [Pubmed]
  5. Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe. Degols, G., Russell, P. Mol. Cell. Biol. (1997) [Pubmed]
  6. The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast. Smith, D.A., Toone, W.M., Chen, D., Bahler, J., Jones, N., Morgan, B.A., Quinn, J. J. Biol. Chem. (2002) [Pubmed]
  7. The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast. Stettler, S., Warbrick, E., Prochnik, S., Mackie, S., Fantes, P. J. Cell. Sci. (1996) [Pubmed]
  8. The fission yeast stress MAPK cascade regulates the pmp3(+) gene that encodes a highly conserved plasma membrane protein. Wang, L.Y., Shiozaki, K. FEBS Lett. (2006) [Pubmed]
  9. Unique regulation of glyoxalase I activity during osmotic stress response in the fission yeast Schizosaccharomyces pombe: neither the mRNA nor the protein level of glyoxalase I increase under conditions that enhance its activity. Takatsume, Y., Izawa, S., Inoue, Y. Arch. Microbiol. (2005) [Pubmed]
  10. Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2. Chung, K.S., Won, M., Lee, S.B., Jang, Y.J., Hoe, K.L., Kim, D.U., Lee, J.W., Kim, K.W., Yoo, H.S. J. Biol. Chem. (2001) [Pubmed]
  11. Expression of hsp16 in response to nucleotide depletion is regulated via the spc1 MAPK pathway in Schizosaccharomyces pombe. Taricani, L., Feilotter, H.E., Weaver, C., Young, P.G. Nucleic Acids Res. (2001) [Pubmed]
  12. Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1. Asp, E., Sunnerhagen, P. Mol. Genet. Genomics (2003) [Pubmed]
  13. Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe. Mutoh, N., Nakagawa, C.W., Yamada, K. Curr. Genet. (2002) [Pubmed]
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