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Chemical Compound Review

GLYOXALASE I     [3-hydroxy-4,5- bis(hydroxymethyl)-2-(3...

Synonyms: Glyo-I, MS-3, NSC-302378, CTK8D4987, NSC302378, ...
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Disease relevance of GLYOXALASE I


Psychiatry related information on GLYOXALASE I


High impact information on GLYOXALASE I

  • Two electrophoretically distinct variants of glyoxalase I (Glo-I) are present in mouse (Mus musculus) [7].
  • Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2 [7].
  • Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis [8].
  • Overexpression of glyoxalase-I completely prevented both hyperglycemia-induced AGE formation and increased macromolecular endocytosis [8].
  • The haplotype containing this rare set of complement alleles always carried the rare HLA allele, HLA-Bw47, usually carried HLA-A3, and almost always had the alleles HLA-Cw6, HLA-DR7, and the glyoxalase I (GLO) allele GLO1 [1].

Chemical compound and disease context of GLYOXALASE I


Biological context of GLYOXALASE I


Anatomical context of GLYOXALASE I


Associations of GLYOXALASE I with other chemical compounds


Gene context of GLYOXALASE I


Analytical, diagnostic and therapeutic context of GLYOXALASE I


  1. Extended MHC haplotypes in 21-hydroxylase-deficiency congenital adrenal hyperplasia: shared genotypes in unrelated patients. Fleischnick, E., Awdeh, Z.L., Raum, D., Granados, J., Alosco, S.M., Crigler, J.F., Gerald, P.S., Giles, C.M., Yunis, E.J., Alper, C.A. Lancet (1983) [Pubmed]
  2. A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major. Vickers, T.J., Greig, N., Fairlamb, A.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Role for glyoxalase I in Alzheimer's disease. Chen, F., Wollmer, M.A., Hoerndli, F., Münch, G., Kuhla, B., Rogaev, E.I., Tsolaki, M., Papassotiropoulos, A., Götz, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida. Kim, N.S., Umezawa, Y., Ohmura, S., Kato, S. J. Biol. Chem. (1993) [Pubmed]
  5. Structure/function relationships in nickel metallobiochemistry. Maroney, M.J. Current opinion in chemical biology. (1999) [Pubmed]
  6. Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder. Politi, P., Minoretti, P., Falcone, C., Martinelli, V., Emanuele, E. Neurosci. Lett. (2006) [Pubmed]
  7. Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2. Meo, T., Douglas, T., Rijnbeek, A.M. Science (1977) [Pubmed]
  8. Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. Shinohara, M., Thornalley, P.J., Giardino, I., Beisswenger, P., Thorpe, S.R., Onorato, J., Brownlee, M. J. Clin. Invest. (1998) [Pubmed]
  9. Increased levels of methylglyoxal-metabolizing enzymes in mononuclear and polymorphonuclear cells from insulin-dependent diabetic patients with diabetic complications: aldose reductase, glyoxalase I, and glyoxalase II--a clinical research center study. Ratliff, D.M., Vander Jagt, D.J., Eaton, R.P., Vander Jagt, D.L. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  10. Mutagenesis of residue 157 in the active site of human glyoxalase I. Ridderström, M., Cameron, A.D., Jones, T.A., Mannervik, B. Biochem. J. (1997) [Pubmed]
  11. Identification and characterization of TspA, a major CD4(+) T-cell- and B-cell-stimulating Neisseria-specific antigen. Kizil, G., Todd, I., Atta, M., Borriello, S.P., Ait-Tahar, K., Ala'Aldeen, D.A. Infect. Immun. (1999) [Pubmed]
  12. Inhibition of proliferation of human leukaemia 60 cells by diethyl esters of glyoxalase inhibitors in vitro. Lo, T.W., Thornalley, P.J. Biochem. Pharmacol. (1992) [Pubmed]
  13. A possible regulatory role of 17beta-estradiol and tamoxifen on glyoxalase I and glyoxalase II genes expression in MCF7 and BT20 human breast cancer cells. Rulli, A., Antognelli, C., Prezzi, E., Baldracchini, F., Piva, F., Giovannini, E., Talesa, V. Breast Cancer Res. Treat. (2006) [Pubmed]
  14. An unusual "morphologic" variant of BF S. Raum, D., Surgenor, T., Awdeh, Z., Marcus, D., Blumenthal, M., Yunis, E.J., Alper, C.A. Am. J. Hum. Genet. (1984) [Pubmed]
  15. Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE. Van Herreweghe, F., Mao, J., Chaplen, F.W., Grooten, J., Gevaert, K., Vandekerckhove, J., Vancompernolle, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  16. Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis. Sakamoto, H., Mashima, T., Kizaki, A., Dan, S., Hashimoto, Y., Naito, M., Tsuruo, T. Blood (2000) [Pubmed]
  17. Activity of the Yap1 transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis. Maeta, K., Izawa, S., Okazaki, S., Kuge, S., Inoue, Y. Mol. Cell. Biol. (2004) [Pubmed]
  18. A new variant glyoxalase I allele that is readily detectable in stimulated lymphocytes and lymphoblastoid cell lines but not in circulating lymphocytes or erythrocytes. Kavathas, P., DeMars, R. Am. J. Hum. Genet. (1981) [Pubmed]
  19. Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells. Kavathas, P., Bach, F.H., DeMars, R. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  20. Glyoxalase I Is Critical for Human Retinal Capillary Pericyte Survival under Hyperglycemic Conditions. Miller, A.G., Smith, D.G., Bhat, M., Nagaraj, R.H. J. Biol. Chem. (2006) [Pubmed]
  21. Cloning and characterization of human colon glyoxalase-I. Ranganathan, S., Walsh, E.S., Godwin, A.K., Tew, K.D. J. Biol. Chem. (1993) [Pubmed]
  22. Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors. Ciaccio, P.J., Shen, H., Jaiswal, A.K., Lyttle, M.H., Tew, K.D. Mol. Pharmacol. (1995) [Pubmed]
  23. Purification and characterization of S-phenacylglutathione reductase from rat liver. Kitada, M., McLenithan, J.C., Anders, M.W. J. Biol. Chem. (1985) [Pubmed]
  24. Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification. Dobler, D., Ahmed, N., Song, L., Eboigbodin, K.E., Thornalley, P.J. Diabetes (2006) [Pubmed]
  25. Evidence for a (triosephosphate isomerase-like) "catalytic loop" near the active site of glyoxalase I. Lan, Y., Lu, T., Lovett, P.S., Creighton, D.J. J. Biol. Chem. (1995) [Pubmed]
  26. Deuterium isotope effects on the product partitioning of fluoromethylglyoxal by glyoxalase I. Proof of a proton transfer mechanism. Chari, R.V., Kozarich, J.W. J. Biol. Chem. (1981) [Pubmed]
  27. Identification of the structural gene for glyoxalase I from Saccharomyces cerevisiae. Inoue, Y., Kimura, A. J. Biol. Chem. (1996) [Pubmed]
  28. Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells. Sakamoto, H., Mashima, T., Sato, S., Hashimoto, Y., Yamori, T., Tsuruo, T. Clin. Cancer Res. (2001) [Pubmed]
  29. Possible assignment of the glyoxalase I (GLO) gene to chromosome 6 using man-mouse somatic cell hybrids. Bender, K., Grzeschik, K.H. Hum. Genet. (1976) [Pubmed]
  30. The locus for glyoxalase i (GLO) is between HLA-A and PGM3 on chromosome 6 of man. Meera Khan, P., Volkers, W.S., Doppert, B.A., Bijnen, A.B., Schreuder, I., van Rood, J.J. Cytogenet. Cell Genet. (1976) [Pubmed]
  31. Anti-glycation defences in yeast. Ponces Freire, A., Ferreira, A., Gomes, R., Cordeiro, C. Biochem. Soc. Trans. (2003) [Pubmed]
  32. Yeast glyoxalase I is a monomeric enzyme with two active sites. Frickel, E.M., Jemth, P., Widersten, M., Mannervik, B. J. Biol. Chem. (2001) [Pubmed]
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