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Gene Review:

Il17a - interleukin 17A

Rattus norvegicus

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Disease relevance of Il17

Levels of IL-17 were elevated in the ischemic hemispheres of human brain compared with the opposite normal hemispheres and peaked at days 3-5 after brain ischemia [1].
Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and function have remained unclear [2].
CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17 [3].

High impact information on Il17

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 [2].
Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T helper cells that produce IL-17 [2].
Neutrophil recruitment by interleukin-17 into rat airways in vivo. Role of tachykinins [4].
The role of interleukin-17 in inducible nitric oxide synthase-mediated nitric oxide production in endothelial cells [5].
Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes [6].

Anatomical context of Il17

We suggest that in additional to T cells the neuroglial cell may be another cellular origin of IL-17 in later progression of brain ischemia [1].
In pMCAO-operated rats, our findings suggest that IL-17 is produced by the neuroglial cells in the brain region undergoing ischemic insult [1].
In contrast, IL-17 was unable to stimulate NO synthesis in either murine or rat macrophages [6].
RESULTS: Asimadoline significantly decreased arthritis severity at day 13, with a concomitant decrease in synovial membrane expression of cytokines interleukin-17 and transforming growth factor-beta (TGF-beta) mRNA at day 13, and no change in T cell numbers in the joints of arthritic rats [7].
Our findings also demonstrate that IL-17 might be a potential contributor to the inflammatory angiogenesis via induction of proangiogenic factors by stromal fibroblasts [8].

Associations of Il17 with chemical compounds

Having in mind a well-known neurotoxic action of NO, these results suggest a possible role for IL-17 in the inflammatory diseases of the CNS [6].
Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis [9].

Analytical, diagnostic and therapeutic context of Il17

The expression of IL-17 mRNA in rat was assayed using oligoprobe in situ hybridization [1].
The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models [10].
Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein [11].
Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection [12].

References

Expression of interleukin-17 in ischemic brain tissue. Li, G.Z., Zhong, D., Yang, L.M., Sun, B., Zhong, Z.H., Yin, Y.H., Cheng, J., Yan, B.B., Li, H.L. Scand. J. Immunol. (2005) [Pubmed]
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Park, H., Li, Z., Yang, X.O., Chang, S.H., Nurieva, R., Wang, Y.H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., Dong, C. Nat. Immunol. (2005) [Pubmed]
CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17. Rice, L., Orlow, D., Ceonzo, K., Stahl, G.L., Tzianabos, A.O., Wada, H., Aird, W.C., Buras, J.A. J. Infect. Dis. (2005) [Pubmed]
Neutrophil recruitment by interleukin-17 into rat airways in vivo. Role of tachykinins. Hoshino, H., Lötvall, J., Skoogh, B.E., Lindén, A. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
The role of interleukin-17 in inducible nitric oxide synthase-mediated nitric oxide production in endothelial cells. Miljkovic, D.j., Cvetkovic, I., Vuckovic, O., Stosic-Grujicic, S., Mostarica Stojkovic, M., Trajkovic, V. Cell. Mol. Life Sci. (2003) [Pubmed]
Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes. Trajkovic, V., Stosic-Grujicic, S., Samardzic, T., Markovic, M., Miljkovic, D., Ramic, Z., Mostarica Stojkovic, M. J. Neuroimmunol. (2001) [Pubmed]
The kappa-opioid agonist, asimadoline, alters cytokine gene expression in adjuvant arthritis. Bush, K.A., Kirkham, B.W., Walker, J.S. Rheumatology (Oxford, England) (2001) [Pubmed]
Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts. Numasaki, M., Lotze, M.T., Sasaki, H. Immunol. Lett. (2004) [Pubmed]
Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis. Pacquelet, S., Presle, N., Boileau, C., Dumond, H., Netter, P., Martel-Pelletier, J., Pelletier, J.P., Terlain, B., Jouzeau, J.Y. J. Rheumatol. (2002) [Pubmed]
The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Lubberts, E., Koenders, M.I., van den Berg, W.B. Arthritis Res. Ther. (2005) [Pubmed]
Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Bush, K.A., Farmer, K.M., Walker, J.S., Kirkham, B.W. Arthritis Rheum. (2002) [Pubmed]
Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. Loong, C.C., Hsieh, H.G., Lui, W.Y., Chen, A., Lin, C.Y. J. Pathol. (2002) [Pubmed]

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