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Gene Review

GABRP  -  gamma-aminobutyric acid (GABA) A receptor, pi

Homo sapiens

Synonyms: GABA(A) receptor subunit pi, Gamma-aminobutyric acid receptor subunit pi
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Disease relevance of GABRP

  • Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue [1].
  • Analysis of the cancer profiling array revealed a more than 2-fold downregulation of GABRP (p < 0.001) in 76% of primary breast carcinomas (n = 50) compared to corresponding normal tissues [1].
  • Non-radioisotopic ISH showed strong GABRP expression in normal epithelial and benign papilloma breast cells, but no signal could be detected in invasive ductal carcinoma [1].

High impact information on GABRP

  • The GABRA1 and GABRP findings were replicated in the second stage in an independent German family-based sample (P=0.0015-0.043) [2].
  • In the first stage, associations were detected in a Portuguese patient sample with single nucleotide polymorphisms (SNPs) and haplotypes in GABRA1 (P=0.00062-0.048), GABRP (P=0.0024-0.042), and GABRA6 (P=0.0065-0.0088) [2].
  • Using cDNA dot blot hybridisation (cancer profiling array), quantitative RT-PCR and non-radioisotopic in situ hybridisation (ISH), we have analysed GABRP expression in breast cancer and normal breast tissues as well as in nontumorigenic and tumorigenic breast cell lines [1].
  • Furthermore, a significant downregulation of GABRP was noted in large (pT3-pT4) (p = 0.044) primary breast tumours [1].
  • GABRP is located on chromosome 5q34 and it encodes the pi-subunit of the gamma-aminobutyric acid (GABA) receptor, a transmembrane protein expressed in the brain and several nonneuronal tissues [1].

Chemical compound and disease context of GABRP


Biological context of GABRP

  • We had observed markedly elevated gene expression of gamma-aminobutyric acid type A (GABA(A)) receptor subunit pi (GABApi, GABRP) in some breast cancers with ER-/HER2- phenotype [3].
  • The GABRP gene has been previously identified by in silico analysis of four million ESTs as a candidate gene differentially expressed in breast cancer [1].

Other interactions of GABRP

  • METHOD: Using this assay, peripheral blood samples were analyzed for expression levels of mammaglobin and three complementary transcribed breast cancer-specific genes: B305D, gamma-aminobutyrate type A receptor pi subunit (GABA pi; GABRP), and B726P [4].

Analytical, diagnostic and therapeutic context of GABRP

  • Quantitative RT-PCR in a panel of 23 normal human tissues showed that the GABRP expression level was most abundant in the normal breast tissues compared to other human tissues [1].


  1. Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue. Zafrakas, M., Chorovicer, M., Klaman, I., Kristiansen, G., Wild, P.J., Heindrichs, U., Knüchel, R., Dahl, E. Int. J. Cancer (2006) [Pubmed]
  2. Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. Petryshen, T.L., Middleton, F.A., Tahl, A.R., Rockwell, G.N., Purcell, S., Aldinger, K.A., Kirby, A., Morley, C.P., McGann, L., Gentile, K.L., Waggoner, S.G., Medeiros, H.M., Carvalho, C., Macedo, A., Albus, M., Maier, W., Trixler, M., Eichhammer, P., Schwab, S.G., Wildenauer, D.B., Azevedo, M.H., Pato, M.T., Pato, C.N., Daly, M.J., Sklar, P. Mol. Psychiatry (2005) [Pubmed]
  3. A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding. Symmans, W.F., Fiterman, D.J., Anderson, S.K., Ayers, M., Rouzier, R., Dunmire, V., Stec, J., Valero, V., Sneige, N., Albarracin, C., Wu, Y., Ross, J.S., Wagner, P., Theriault, R.L., Arun, B., Kuerer, H., Hess, K.R., Zhang, W., Hortobagyi, G.N., Pusztai, L. Endocr. Relat. Cancer (2005) [Pubmed]
  4. Detection of circulating tumor cells in peripheral blood of breast cancer patients during or after therapy using a multigene real-time RT-PCR assay. Zehentner, B.K., Secrist, H., Hayes, D.C., Zhang, X., Ostenson, R.C., Loop, S., Goodman, G., Houghton, R.L., Persing, D.H. Molecular diagnosis & therapy. (2006) [Pubmed]
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