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Gene Review

CHRDL2  -  chordin-like 2

Homo sapiens

Synonyms: BNF-1, BNF1, Breast tumor novel factor 1, CHL2, Chordin-like protein 2, ...
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Disease relevance of CHRDL2

  • We show here that BNF-1 is over-expressed not only in breast tumors but also in lung and colon tumors [1].

High impact information on CHRDL2

  • CHL2 depressed chondrocyte mineralization when added during the hypertrophic differentiation of cultured hyaline cartilage particles [2].
  • Adult mesenchymal progenitor cells expressed CHL2, and its levels decreased during chondrogenic differentiation [2].
  • In situ hybridization revealed that CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs [2].
  • In this study, we compared the levels of lipid peroxidation and oxidatively modified proteins in plasma and splenocytes, and the mitogen-induced T lymphocyte proliferation in ad lib-fed (AL) and caloric restricted (CR) Fischer 344 x BNF1 male rats at the ages of 5, 18, and 31 months [3].
  • Extensive and complex alternative splicing of hCHL2 was observed in different tissues, resulting in several distinct protein isoforms that vary substantially in the presence of a signal peptide and their content of CR domains [4].

Biological context of CHRDL2

  • Potassium depletion: renal membrane lipid metabolism and Na/H exchanger abundance in aged F344 x BNF1 rats [5].

Anatomical context of CHRDL2

  • However, CHL2 expression was upregulated in middle zone chondrocytes in osteoarthritic joint cartilage (where hypertrophic markers are induced) [2].
  • Expression of hCHL2 mRNA and protein was detected in a variety of human tissues and is particularly abundant in the uterus [4].
  • Differential expression of CHL2 variants was observed during myoblast and osteoblast differentiation, implying a role for this gene in these physiological processes [4].
  • PCR analysis of BNF-1 expression in a variety of human adult normal tissues revealed that BNF-1 is expressed predominantly in liver, heart, prostate, testis, and ovary [1].

Other interactions of CHRDL2


  1. BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues. Wu, I., Moses, M.A. Gene (2003) [Pubmed]
  2. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Nakayama, N., Han, C.Y., Cam, L., Lee, J.I., Pretorius, J., Fisher, S., Rosenfeld, R., Scully, S., Nishinakamura, R., Duryea, D., Van, G., Bolon, B., Yokota, T., Zhang, K. Development (2004) [Pubmed]
  3. Effects of caloric restriction on age-related oxidative modifications of macromolecules and lymphocyte proliferation in rats. Tian, L., Cai, Q., Bowen, R., Wei, H. Free Radic. Biol. Med. (1995) [Pubmed]
  4. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Oren, A., Toporik, A., Biton, S., Almogy, N., Eshel, D., Bernstein, J., Savitsky, K., Rotman, G. Gene (2004) [Pubmed]
  5. Potassium depletion: renal membrane lipid metabolism and Na/H exchanger abundance in aged F344 x BNF1 rats. Eiam-Ong, S., Sabatini, S. J. Gerontol. A Biol. Sci. Med. Sci. (1999) [Pubmed]
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