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Gene Review

mt-Nd1  -  NADH dehydrogenase 1, mitochondrial

Rattus norvegicus

Synonyms: Mtnd1, NADH dehydrogenase subunit 1, NADH-ubiquinone oxidoreductase chain 1, ND1, Nd1
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High impact information on mt-Nd1

  • The polycistronic RNAs were products of the heavy strand of the mitochondrial genome, and major species demonstrated hybridization patterns consistent with identifications corresponding to the 12-16 S rRNA, 12-16 S-ND1, 16 S-ND1, and CO II-ATP synthase subunit 6 regions of the mitochondrial genome [1].
  • After 2 weeks of HCCL treatment, hepatic contents of the mature mitochondrial mRNAs (expressed normalized to 28 S rRNA) encoding subunit II of cytochrome c oxidase (CO II), subunit 1 of NADH dehydrogenase (ND1), and cytochrome b were reduced to values 40-60% of those observed in RNA from control liver tissue [1].
  • Oxidant exposure rapidly produced a large mtDNA deletion involving the coding regions for cytochrome c oxidase (COX 1) and NADH dehydrogenase (ND1 and ND2) [2].
  • In addition, troglitazone treatment restored ND1 and PGC-1 expression in skeletal muscle [3].
  • Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone [3].

Biological context of mt-Nd1


Anatomical context of mt-Nd1

  • In the present study, we investigated the effect of Ginkgo biloba extract, EGb 761, and one of its components, bilobalide, on gene expression of subunit 1 of mitochondrial NADH dehydrogenase (ND1) in PC12 cells [5].

Associations of mt-Nd1 with chemical compounds

  • The shift from glucose to fatty acids as the source of energy in skeletal muscle of ZDF rats was accompanied by a reduction of subunit 1 of complex I (NADH dehydrogenase subunit 1, ND1) and subunit II of complex IV (cytochrome c oxidase II, COII), two genes of the electronic transport chain encoded by mtDNA [3].

Other interactions of mt-Nd1

  • Nondenaturing electrophoresis separated C-BVR-T and B-BVR-T preparations into groups of four variants, designated as BVR ND1 to ND4 [7].
  • METHODS: Augmenter of liver regeneration protein was injected in intact rats and, in the hepatic tissue, the expression of two genes located in two different regions of the mitochondrial genome, mitochondrial ATPase 6/8, and ND1 subunit, and of a nuclear gene, mitochondrial Transcription Factor A, were considered [8].

Analytical, diagnostic and therapeutic context of mt-Nd1

  • Sequence analysis of the rat ND1 gene indicates that the maternally transferred factor in the rat is not a homologue of the maternally transmitted factor responsible for the mitochondrial antigen in mice [9].
  • The level of mRNA for ND1 through Northern blot analysis gradually increased from birth to 15 days of age and was highest at 21 days [10].


  1. Hepatic cobalamin deficiency induced by hydroxycobalamin[c-lactam] treatment in rats is associated with decreased mitochondrial mRNA contents and accumulation of polycistronic mitochondrial RNAs. Leeds, F.S., Brass, E.P. J. Biol. Chem. (1994) [Pubmed]
  2. Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Suliman, H.B., Carraway, M.S., Velsor, L.W., Day, B.J., Ghio, A.J., Piantadosi, C.A. Free Radic. Biol. Med. (2002) [Pubmed]
  3. Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. Jové, M., Salla, J., Planavila, A., Cabrero, A., Michalik, L., Wahli, W., Laguna, J.C., Vázquez-Carrera, M. J. Lipid Res. (2004) [Pubmed]
  4. Nucleotide sequence of rat mitochondrial NADH dehydrogenase subunit 1. GTG, a new initiator codon in vertebrate mitochondrial genome. Gadaleta, G., Pepe, G., De Candia, G., Quagliariello, C., Sbisà, E., Saccone, C. Nucleic Acids Res. (1988) [Pubmed]
  5. Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Tendi, E.A., Bosetti, F., Dasgupta, S.F., Stella, A.M., Drieu, K., Rapoport, S.I. Neurochem. Res. (2002) [Pubmed]
  6. Thyromimetic action of the peroxisome proliferators clofibrate, perfluorooctanoic acid, and acetylsalicylic acid includes changes in mRNA levels for certain genes involved in mitochondrial biogenesis. Cai, Y., Nelson, B.D., Li, R., Luciakova, K., dePierre, J.W. Arch. Biochem. Biophys. (1996) [Pubmed]
  7. Multiple forms of biliverdin reductase: modification of the pattern of expression in rat liver by bromobenzene. Huang, T.J., Trakshel, G.M., Maines, M.D. Arch. Biochem. Biophys. (1989) [Pubmed]
  8. The augmenter of liver regeneration induces mitochondrial gene expression in rat liver and enhances oxidative phosphorylation capacity of liver mitochondria. Polimeno, L., Capuano, F., Marangi, L.C., Margiotta, M., Lisowsky, T., Ierardi, E., Francavilla, R., Francavilla, A. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. (2000) [Pubmed]
  9. Generation of T cells with lytic specificity for atypical antigens. I. A mitochondrial antigen in the rat. Davies, J.D., Wilson, D.H., Hermel, E., Lindahl, K.F., Butcher, G.W., Wilson, D.B. J. Exp. Med. (1991) [Pubmed]
  10. NADH-O2 oxidoreductase activity and mRNA expression of complex I (51 kDa, ND1) in postnatal intrinsic muscle of rat tongue. Fujita, T., Sato, I. J. Anat. (2003) [Pubmed]
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