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Gene Review

mt-Nd2  -  NADH dehydrogenase 2, mitochondrial

Rattus norvegicus

Synonyms: Mtnd2, NADH dehydrogenase subunit 2, NADH-ubiquinone oxidoreductase chain 2, ND2, Nd2
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High impact information on mt-Nd2

  • The presence of a curved DNA sequence in the gene for the NADH-dehydrogenase subunit 2 of rat mitochondrial genome, upstream from the origin of the light strand replication have been demonstrated through theoretical analysis and experimental approaches [1].
  • Oxidant exposure rapidly produced a large mtDNA deletion involving the coding regions for cytochrome c oxidase (COX 1) and NADH dehydrogenase (ND1 and ND2) [2].
  • Dimethyl sulfate footprinting has allowed the detection of a protein-DNA interaction within the curved ND2 region with contact sites located in both the strands [3].
  • Furthermore, BVR ND3 exhibited a higher catalytic rate than BVR ND2 with either cofactor throughout the pH range 6.5-9 [4].
  • Cellular DNA of the inbred mouse strains BALB/c, C3Hf, C57BL, CBA, DBAf , GRS and ND2 and the inbred rat strains BN, SD and WAG was shown to oncogenically transform murine fibroblasts of the continuous cell line BALB/3T3 [5].


  1. Isolation of a 25-kDa protein binding to a curved DNA upstream the origin of the L strand replication in the rat mitochondrial genome. Gadaleta, G., D'Elia, D., Capaccio, L., Saccone, C., Pepe, G. J. Biol. Chem. (1996) [Pubmed]
  2. Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Suliman, H.B., Carraway, M.S., Velsor, L.W., Day, B.J., Ghio, A.J., Piantadosi, C.A. Free Radic. Biol. Med. (2002) [Pubmed]
  3. In organello footprinting analysis of rat mitochondrial DNA: protein interaction upstream of the Ori-L. Cingolani, G., Capaccio, L., D'Elia, D., Gadaleta, G. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  4. Multiple forms of biliverdin reductase: modification of the pattern of expression in rat liver by bromobenzene. Huang, T.J., Trakshel, G.M., Maines, M.D. Arch. Biochem. Biophys. (1989) [Pubmed]
  5. Presence of fibroblast-transforming genes in normal DNA of several mouse and rat strains. Bentvelzen, P. European journal of cancer & clinical oncology. (1984) [Pubmed]
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