The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

mt-Nd2  -  NADH dehydrogenase 2, mitochondrial

Rattus norvegicus

Synonyms: Mtnd2, NADH dehydrogenase subunit 2, NADH-ubiquinone oxidoreductase chain 2, ND2, Nd2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on mt-Nd2

  • The presence of a curved DNA sequence in the gene for the NADH-dehydrogenase subunit 2 of rat mitochondrial genome, upstream from the origin of the light strand replication have been demonstrated through theoretical analysis and experimental approaches [1].
  • Oxidant exposure rapidly produced a large mtDNA deletion involving the coding regions for cytochrome c oxidase (COX 1) and NADH dehydrogenase (ND1 and ND2) [2].
  • Dimethyl sulfate footprinting has allowed the detection of a protein-DNA interaction within the curved ND2 region with contact sites located in both the strands [3].
  • Furthermore, BVR ND3 exhibited a higher catalytic rate than BVR ND2 with either cofactor throughout the pH range 6.5-9 [4].
  • Cellular DNA of the inbred mouse strains BALB/c, C3Hf, C57BL, CBA, DBAf , GRS and ND2 and the inbred rat strains BN, SD and WAG was shown to oncogenically transform murine fibroblasts of the continuous cell line BALB/3T3 [5].

References

  1. Isolation of a 25-kDa protein binding to a curved DNA upstream the origin of the L strand replication in the rat mitochondrial genome. Gadaleta, G., D'Elia, D., Capaccio, L., Saccone, C., Pepe, G. J. Biol. Chem. (1996) [Pubmed]
  2. Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Suliman, H.B., Carraway, M.S., Velsor, L.W., Day, B.J., Ghio, A.J., Piantadosi, C.A. Free Radic. Biol. Med. (2002) [Pubmed]
  3. In organello footprinting analysis of rat mitochondrial DNA: protein interaction upstream of the Ori-L. Cingolani, G., Capaccio, L., D'Elia, D., Gadaleta, G. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  4. Multiple forms of biliverdin reductase: modification of the pattern of expression in rat liver by bromobenzene. Huang, T.J., Trakshel, G.M., Maines, M.D. Arch. Biochem. Biophys. (1989) [Pubmed]
  5. Presence of fibroblast-transforming genes in normal DNA of several mouse and rat strains. Bentvelzen, P. European journal of cancer & clinical oncology. (1984) [Pubmed]
 
WikiGenes - Universities