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Gene Review

SLC13A4  -  solute carrier family 13 (sodium/sulfate...

Homo sapiens

Synonyms: Na(+)/sulfate cotransporter SUT-1, NaS2, SUT-1, SUT1, Solute carrier family 13 member 4
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High impact information on SLC13A4


Biological context of SLC13A4


Anatomical context of SLC13A4

  • Altogether, the findings may suggest a role of SUT1 in retrieval of Suc from the apoplasm, thereby regulating the osmotic potential in the extracellular space, or a direct role in phloem unloading acting as a phloem exporter transferring Suc from the sieve elements into the apoplasm [3].

Associations of SLC13A4 with chemical compounds

  • Furthermore, the use of transgenic plants specifically impaired in sucrose transporter expression has provided strong evidence that SUT1 transporter function is required for phloem loading [4].

Other interactions of SLC13A4


  1. Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. Girard, J.P., Baekkevold, E.S., Feliu, J., Brandtzaeg, P., Amalric, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4). Markovich, D., Regeer, R.R., Kunzelmann, K., Dawson, P.A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  3. The sucrose transporter StSUT1 localizes to sieve elements in potato tuber phloem and influences tuber physiology and development. Kühn, C., Hajirezaei, M.R., Fernie, A.R., Roessner-Tunali, U., Czechowski, T., Hirner, B., Frommer, W.B. Plant Physiol. (2003) [Pubmed]
  4. Sucrose transport in higher plants. Ward, J.M., Kühn, C., Tegeder, M., Frommer, W.B. Int. Rev. Cytol. (1998) [Pubmed]
  5. The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. Lee, A., Beck, L., Markovich, D. Genomics (2000) [Pubmed]
  6. Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. Li, H., Pajor, A.M. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
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