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Gene Review:

SNORD34 - small nucleolar RNA, C/D box 34

Homo sapiens

Synonyms: RNU34, U34

Pei, J. et al., Lin, B. et al., Guzman, J. et al., Tan, Y. et al., De Biase, A. et al., et al.

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Disease relevance of SNORD34

Peptidase family U34 consists of enzymes with unclear catalytic mechanism, for instance, dipeptidase A from Lactobacillus helveticus [1].

High impact information on SNORD34

METHODS: Gene expression array analysis ([RG-U34] GeneChip) was performed in normal and transformed rat intestinal epithelial cells before and after exposures to celecoxib [2].
High-density oligonucleotide microarray analysis of gene dysregulation was assessed in colons from normal, TNBS-treated (7 days), and oral IB-MECA-treated rats (1.5 mg/kg b.i.d.) using a rat RNU34 neural GeneChip of 724 genes and SYBR green polymerase chain reaction [3].
RESULTS: Primary rat hepatocytes were exposed to cadmium acetate at 0, 1.25 and 2 microM. mRNA expression profiles at 0, 3, 6, 12 and 24 h were measured using the Affymetrix RatTox U34 GeneChip arrays [4].
The PVA/U34 family is variable in sequence and exhibits great diversity in substrate specificity, to include enzymes such as choloyglycine hydrolases, acid ceramidases, isopenicillin N acyltransferases, and a subgroup of eukaryotic proteins with unclear function [1].
We utilized rat neurobiology U34 array to measure gene expression changes in whole brain tissue of rats exposed repeatedly to JP-8, under conditions that simulated possible occupational exposure (6 h/day for 91 days) to JP-8 vapor at 250, 500, and 1000 mg/m(3), respectively [5].

Biological context of SNORD34

High-density oligonucleotide microarrays were used that included approximately 27,000 genes/ESTs (Affymetrix RG-U34; A, B and C arrays), together with multiple analyses (MAS 5.0, dChip) [6].

Associations of SNORD34 with chemical compounds

Analysis using an Affymetrix GeneChip U34 revealed that the expression levels of 195 genes were changed by the treatment with amlodipine [7].

References

Peptidase family U34 belongs to the superfamily of N-terminal nucleophile hydrolases. Pei, J., Grishin, N.V. Protein Sci. (2003) [Pubmed]
CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis. Sagiv, E., Memeo, L., Karin, A., Kazanov, D., Jacob-Hirsch, J., Mansukhani, M., Rechavi, G., Hibshoosh, H., Arber, N. Gastroenterology (2006) [Pubmed]
ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis. Guzman, J., Yu, J.G., Suntres, Z., Bozarov, A., Cooke, H., Javed, N., Auer, H., Palatini, J., Hassanain, H.H., Cardounel, A.J., Javed, A., Grants, I., Wunderlich, J.E., Christofi, F.L. Inflamm. Bowel Dis. (2006) [Pubmed]
Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmium. Tan, Y., Shi, L., Hussain, S.M., Xu, J., Tong, W., Frazier, J.M., Wang, C. Bioinformatics (2006) [Pubmed]
Gene expression profiles in the rat central nervous system induced by JP-8 jet fuel vapor exposure. Lin, B., Ritchie, G.D., Rossi, J., Pancrazio, J.J. Neurosci. Lett. (2004) [Pubmed]
Gene expression profiling of experimental traumatic spinal cord injury as a function of distance from impact site and injury severity. De Biase, A., Knoblach, S.M., Di Giovanni, S., Fan, C., Molon, A., Hoffman, E.P., Faden, A.I. Physiol. Genomics (2005) [Pubmed]
Amelioration of hypertensive heart failure by amlodipine may occur via antioxidative effects. Hasegawa, H., Takano, H., Kohro, T., Ueda, K., Niitsuma, Y., Aburatani, H., Komuro, I. Hypertens. Res. (2006) [Pubmed]

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