The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

UL10  -  type 3 membrane protein; 8 transmembrane...

Human herpesvirus 1

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of UL10


High impact information on UL10

  • Transcriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed-early gene product, OBPC [4].
  • (iii) The UL10 protein in cells treated with tunicamycin formed a single band (apparent M(r) of 47,000) reactive with the anti-UL10 antibody, indicating that the 47,000-M(r) protein was a precursor of N-glycosylated, more slowly migrating forms of UL10 [1].
  • R7216 contains a 972-bp deletion within the 1,419-bp open reading frame of UL10, whereas R7210 lacks 988 bp of the 1,119-bp UL16 open reading frame [5].
  • None of these UL10 gene products is modified by N- or O-linked glycosylation [6].
  • To investigate its role in vivo a deletion mutant lacking the majority of the UL10 open reading frame was constructed (UL10-del) [7].

Chemical compound and disease context of UL10


Biological context of UL10

  • The two novel mutations localized in EcoRI-d fragment were further finely mapped, and it was demonstrated that the mutations belonging to groups E and H were involved in the open reading frames UL10 and UL13, respectively [8].
  • We have mapped and characterized the overlapping transcripts in this region and have found that, in addition to the low-abundance UL8 and UL9 transcripts and the abundant UL10 transcript, at least two additional transcription units, designated UL8.5 and UL9.5, are specified by this region of the genome [4].
  • On the basis of predicted amino acid sequence characteristics, herpes simplex virus type 1 gene UL10 is thought likely to encode a membrane protein with eight potential transmembrane regions [7].


  1. The UL10 gene of herpes simplex virus 1 encodes a novel viral glycoprotein, gM, which is present in the virion and in the plasma membrane of infected cells. Baines, J.D., Roizman, B. J. Virol. (1993) [Pubmed]
  2. Intracellular processing of pseudorabies virus glycoprotein M (gM): gM of strain Bartha lacks N-glycosylation. Dijkstra, J.M., Mettenleiter, T.C., Klupp, B.G. Virology (1997) [Pubmed]
  3. Identification and structure of the Marek's disease virus serotype 2 glycoprotein M gene: comparison with glycoprotein M genes of Herpesviridae family. Cai, J.S., Jang, H.K., Izumiya, Y., Tsushima, Y., Kato, K., Damiani, A.M., Miyazawa, T., Kai, C., Takahashi, E., Mikami, T. J. Vet. Med. Sci. (1999) [Pubmed]
  4. Transcriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed-early gene product, OBPC. Baradaran, K., Dabrowski, C.E., Schaffer, P.A. J. Virol. (1994) [Pubmed]
  5. The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture. Baines, J.D., Roizman, B. J. Virol. (1991) [Pubmed]
  6. DNA sequence of the UL6 to UL20 genes of infectious laryngotracheitis virus and characterization of the UL10 gene product as a nonglycosylated and nonessential virion protein. Fuchs, W., Mettenleiter, T.C. J. Gen. Virol. (1999) [Pubmed]
  7. Characterization of the UL10 gene product of herpes simplex virus type 1 and investigation of its role in vivo. MacLean, C.A., Robertson, L.M., Jamieson, F.E. J. Gen. Virol. (1993) [Pubmed]
  8. Two novel genes of herpes simplex virus type 1 involved in cell fusion. Yamamoto, S., Hamada, N., Shingu, M. The Kurume medical journal. (1993) [Pubmed]
WikiGenes - Universities