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Gene Review

UL10  -  type 3 membrane protein; 8 transmembrane...

Human herpesvirus 1

 
 
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Disease relevance of UL10

 

High impact information on UL10

  • Transcriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed-early gene product, OBPC [4].
  • (iii) The UL10 protein in cells treated with tunicamycin formed a single band (apparent M(r) of 47,000) reactive with the anti-UL10 antibody, indicating that the 47,000-M(r) protein was a precursor of N-glycosylated, more slowly migrating forms of UL10 [1].
  • R7216 contains a 972-bp deletion within the 1,419-bp open reading frame of UL10, whereas R7210 lacks 988 bp of the 1,119-bp UL16 open reading frame [5].
  • None of these UL10 gene products is modified by N- or O-linked glycosylation [6].
  • To investigate its role in vivo a deletion mutant lacking the majority of the UL10 open reading frame was constructed (UL10-del) [7].
 

Chemical compound and disease context of UL10

 

Biological context of UL10

  • The two novel mutations localized in EcoRI-d fragment were further finely mapped, and it was demonstrated that the mutations belonging to groups E and H were involved in the open reading frames UL10 and UL13, respectively [8].
  • We have mapped and characterized the overlapping transcripts in this region and have found that, in addition to the low-abundance UL8 and UL9 transcripts and the abundant UL10 transcript, at least two additional transcription units, designated UL8.5 and UL9.5, are specified by this region of the genome [4].
  • On the basis of predicted amino acid sequence characteristics, herpes simplex virus type 1 gene UL10 is thought likely to encode a membrane protein with eight potential transmembrane regions [7].

References

  1. The UL10 gene of herpes simplex virus 1 encodes a novel viral glycoprotein, gM, which is present in the virion and in the plasma membrane of infected cells. Baines, J.D., Roizman, B. J. Virol. (1993) [Pubmed]
  2. Intracellular processing of pseudorabies virus glycoprotein M (gM): gM of strain Bartha lacks N-glycosylation. Dijkstra, J.M., Mettenleiter, T.C., Klupp, B.G. Virology (1997) [Pubmed]
  3. Identification and structure of the Marek's disease virus serotype 2 glycoprotein M gene: comparison with glycoprotein M genes of Herpesviridae family. Cai, J.S., Jang, H.K., Izumiya, Y., Tsushima, Y., Kato, K., Damiani, A.M., Miyazawa, T., Kai, C., Takahashi, E., Mikami, T. J. Vet. Med. Sci. (1999) [Pubmed]
  4. Transcriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed-early gene product, OBPC. Baradaran, K., Dabrowski, C.E., Schaffer, P.A. J. Virol. (1994) [Pubmed]
  5. The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture. Baines, J.D., Roizman, B. J. Virol. (1991) [Pubmed]
  6. DNA sequence of the UL6 to UL20 genes of infectious laryngotracheitis virus and characterization of the UL10 gene product as a nonglycosylated and nonessential virion protein. Fuchs, W., Mettenleiter, T.C. J. Gen. Virol. (1999) [Pubmed]
  7. Characterization of the UL10 gene product of herpes simplex virus type 1 and investigation of its role in vivo. MacLean, C.A., Robertson, L.M., Jamieson, F.E. J. Gen. Virol. (1993) [Pubmed]
  8. Two novel genes of herpes simplex virus type 1 involved in cell fusion. Yamamoto, S., Hamada, N., Shingu, M. The Kurume medical journal. (1993) [Pubmed]
 
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