Gene Review:
UL8 - helicase-primase subunit
Human herpesvirus 1
- The UL8 subunit of the herpes simplex virus type-1 DNA helicase-primase optimizes utilization of DNA templates covered by the homologous single-strand DNA-binding protein ICP8. Tanguy Le Gac, N., Villani, G., Hoffmann, J.S., Boehmer, P.E. J. Biol. Chem. (1996)
- The herpes simplex virus type 1 origin-binding protein interacts specifically with the viral UL8 protein. McLean, G.W., Abbotts, A.P., Parry, M.E., Marsden, H.S., Stow, N.D. J. Gen. Virol. (1994)
- Deletion mutants of the herpes simplex virus type 1 UL8 protein: effect on DNA synthesis and ability to interact with and influence the intracellular localization of the UL5 and UL52 proteins. Barnard, E.C., Brown, G., Stow, N.D. Virology (1997)
- Association of DNA helicase and primase activities with a subassembly of the herpes simplex virus 1 helicase-primase composed of the UL5 and UL52 gene products. Dodson, M.S., Lehman, I.R. Proc. Natl. Acad. Sci. U.S.A. (1991)
- The UL5 and UL52 subunits of the herpes simplex virus type 1 helicase-primase subcomplex exhibit a complex interdependence for DNA binding. Biswas, N., Weller, S.K. J. Biol. Chem. (2001)
- The UL8 subunit of the heterotrimeric herpes simplex virus type 1 helicase-primase is required for the unwinding of single strand DNA-binding protein (ICP8)-coated DNA substrates. Falkenberg, M., Bushnell, D.A., Elias, P., Lehman, I.R. J. Biol. Chem. (1997)
- The UL8 component of the herpes simplex virus helicase-primase complex stimulates primer synthesis by a subassembly of the UL5 and UL52 components. Tenney, D.J., Hurlburt, W.W., Micheletti, P.A., Bifano, M., Hamatake, R.K. J. Biol. Chem. (1994)
- Transcriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed-early gene product, OBPC. Baradaran, K., Dabrowski, C.E., Schaffer, P.A. J. Virol. (1994)
- Two-hybrid analysis of the interaction between the UL52 and UL8 subunits of the herpes simplex virus type 1 helicase-primase. Constantin, N., Dodson, M.S. J. Gen. Virol. (1999)
- The herpes simplex virus type 1 UL8 protein influences the intracellular localization of the UL52 but not the ICP8 or POL replication proteins in virus-infected cells. Marsden, H.S., Cross, A.M., Francis, G.J., Patel, A.H., MacEachran, K., Murphy, M., McVey, G., Haydon, D., Abbotts, A., Stow, N.D. J. Gen. Virol. (1996)
- Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication. Heilbronn, R., Weller, S.K., zur Hausen, H. Virology (1990)
- The two helicases of herpes simplex virus type 1 (HSV-1). Chattopadhyay, S., Chen, Y., Weller, S.K. Front. Biosci. (2006)
- Functional interaction between the herpes simplex virus type 1 polymerase processivity factor and origin-binding proteins: enhancement of UL9 helicase activity. Trego, K.S., Parris, D.S. J. Virol. (2003)
- A mutation in the C-terminal putative Zn2+ finger motif of UL52 severely affects the biochemical activities of the HSV-1 helicase-primase subcomplex. Biswas, N., Weller, S.K. J. Biol. Chem. (1999)