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Gene Review:

UL54 - RNA-binding protein; shuttles between...

Human herpesvirus 1

Su, Y.H. et al., Beth, E. et al., DeLuca, N.A. et al., Millette, R.L. et al., Whitton, J.L. et al., et al.

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Disease relevance of UL54

Immediate early genes of herpes simplex viruses contain one or more copies of the conserved TAAT-GARAT (where R is purine) DNA motif [1].
Immediate-early (IE) mRNAs-4 and -5 of herpes simplex virus type 2 (HSV-2) are transcribed from the IRs/TRs genome regions towards the Us region [2].
The expression of viral genes during infection of tissue culture cells by herpesviruses can be divided into three broad classes termed Immediate-Early (IE), early and late [3].
Immediate early, early and late antigens synthesized in herpes simplex virus (HSV) type 1 infected cells can be efficiently demonstrated using the sensitive anti-complement immunofluorescence (ACIF) test and highly specific antisera prepared against early or late HSV-1 determined proteins in a syngeneic rat system [4].

High impact information on UL54

Immediate-early mRNA-2 of herpes simplex viruses types 1 and 2 is unspliced: conserved sequences around the 5' and 3' termini correspond to transcription regulatory signals [5].
Evidence that the Immediate-Early Gene Product ICP4 Is Necessary for the Genome of the Herpes Simplex Virus Type 1 ICP4 Deletion Mutant Strain d120 To Circularize in Infected Cells [6].
Immediate-early polypeptides ICP0 and ICP27 were expressed to a higher level in Vero cells infected with an ICP4 temperature-sensitive (ts) mutant (tsB32) at 39 degrees C, indicating immediate-early stimulatory activity associated with the ts ICP4 polypeptide [7].
Immediate early transcription units were analyzed by having cycloheximide present throughout the period of infection, removing the drug at 8 h postinfection, and pulse-labeling proteins with [35S]methionine [8].
Immediate early and/or early viral gene expression was sufficient to induce transformation [9].

Biological context of UL54

The herpes simplex virus type 1 (HSV-1) Immediate-Early (IE) polypeptide Vmw175 is essential for the activation of transcription from viral early and late promoters [10].
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency [11].

Anatomical context of UL54

Immediate-early gene expression is sufficient for induction of natural killer cell-mediated lysis of herpes simplex virus type 1-infected fibroblasts [12].

References

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins. Gerster, T., Roeder, R.G. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
The junctions between the repetitive and the short unique sequences of the herpes simplex virus genome are determined by the polypeptide-coding regions of two spliced immediate-early mRNAs. Whitton, J.L., Clements, J.B. J. Gen. Virol. (1984) [Pubmed]
The regulation of transcription of viral and cellular genes by herpesvirus immediate-early gene products (review). Everett, R.D. Anticancer Res. (1987) [Pubmed]
Detection of immediate early, early and late antigens in herpes simplex virus type 1 infected cells. Beth, E., Giraldo, G., Bernhard, M. Biomedicine / [publiée pour l'A.A.I.C.I.G.]. (1976) [Pubmed]
Immediate-early mRNA-2 of herpes simplex viruses types 1 and 2 is unspliced: conserved sequences around the 5' and 3' termini correspond to transcription regulatory signals. Whitton, J.L., Rixon, F.J., Easton, A.J., Clements, J.B. Nucleic Acids Res. (1983) [Pubmed]
Evidence that the Immediate-Early Gene Product ICP4 Is Necessary for the Genome of the Herpes Simplex Virus Type 1 ICP4 Deletion Mutant Strain d120 To Circularize in Infected Cells. Su, Y.H., Zhang, X., Wang, X., Fraser, N.W., Block, T.M. J. Virol. (2006) [Pubmed]
Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. DeLuca, N.A., McCarthy, A.M., Schaffer, P.A. J. Virol. (1985) [Pubmed]
Gene expression of herpes simplex virus. II. UV radiological analysis of viral transcription units. Millette, R.L., Klaiber, R. J. Virol. (1980) [Pubmed]
Transformation of rodent fibroblasts by herpes simplex virus: presence of morphological transforming region 1 (MTR 1) is not required for the maintenance of the transformed state. Bauer, G., Kahl, S., Sawhney, I.S., Höfler, P., Gerspach, R., Matz, B. Int. J. Cancer (1992) [Pubmed]
Purification of the DNA binding domain of herpes simplex virus type 1 immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of its DNA recognition site. Everett, R.D., Elliott, M., Hope, G., Orr, A. Nucleic Acids Res. (1991) [Pubmed]
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. Leib, D.A., Coen, D.M., Bogard, C.L., Hicks, K.A., Yager, D.R., Knipe, D.M., Tyler, K.L., Schaffer, P.A. J. Virol. (1989) [Pubmed]
Immediate-early gene expression is sufficient for induction of natural killer cell-mediated lysis of herpes simplex virus type 1-infected fibroblasts. Fitzgerald-Bocarsly, P., Howell, D.M., Pettera, L., Tehrani, S., Lopez, C. J. Virol. (1991) [Pubmed]

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