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Gene Review:

CACYBP - calcyclin binding protein

Homo sapiens

Synonyms: CacyBP, Calcyclin-binding protein, GIG5, PNAS-107, S100A6-binding protein, ...

Au, K.W. et al., Zhai, H. et al., Wu, J. et al., Filipek, A., Matsuzawa, S. et al.

Filipek,

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Disease relevance of CACYBP

Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells [1].
When Ca(2+)-dependent interaction of S100A6 with target proteins was studied in Ehrlich ascites tumor cells, a novel protein, now called CacyBP/SIP, was discovered [2].
To investigate the cardioprotective role of CacyBP/SIP in cardiomyocytes, a hypoxia/reoxygenation model was employed [3].
Western blot and immunofluorescence microscopy showed that the MAb BD1 against CacyBP could recognize CacyBP protein derived from human gastric cancer cell lines in both native and denatured forms [4].

High impact information on CACYBP

Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP) [5].
The overexpression of CacyBP/SIP promotes the differentiation and DNA synthesis of H9C2 cells and primary rat cardiomyocytes, as well as downregulates the expression of beta-catenin [3].
We found that CacyBP/SIP was upregulated during myocardial infarction (MI) and hypoxia/reoxygenation [3].
Besides, CacyBP/SIP promotes the formation of myotubes and multinucleation upon differentiation [3].
To show the importance of CacyBP/SIP during myoblast differentiation, we report here that CacyBP/SIP is developmentally regulated in postnatal rat hearts [3].

Biological context of CACYBP

Thus, the phosphorylation of CacyBP occurs when it is translocated to the nuclear region [1].

Associations of CACYBP with chemical compounds

In the RA-induced differentiated SH-SY5Y cells, CacyBP was phosphorylated on serine residue(s), while it existed in a dephosphorylated form in normal (uninduced) cells [1].
BALB/c mouse splenocytes were immunized with purified 6 x His-CacyBP fusion protein and fused with myeloma cells using polyethylene glycol (PEG) 4000 [4].

Other interactions of CACYBP

S100A6 and CacyBP/SIP - two proteins discovered in ehrlich ascites tumor cells that are potentially involved in the degradation of beta-catenin [2].

Analytical, diagnostic and therapeutic context of CACYBP

By selection using enzyme-linked immunosorbent assay (ELISA), three anti-CacyBP MAbs were obtained [4].

References

Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells. Wu, J., Tan, X., Peng, X., Yuan, J., Qiang, B. J. Biochem. Mol. Biol. (2003) [Pubmed]
S100A6 and CacyBP/SIP - two proteins discovered in ehrlich ascites tumor cells that are potentially involved in the degradation of beta-catenin. Filipek, A. Chemotherapy. (2006) [Pubmed]
Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes. Au, K.W., Kou, C.Y., Woo, A.Y., Chim, S.S., Fung, K.P., Cheng, C.H., Waye, M.M., Tsui, S.K. J. Cell. Biochem. (2006) [Pubmed]
Establishment and characterization of calcyclin binding protein (CacyBP) monoclonal antibody. Zhai, H., Shi, Y., Yu, J., Hong, L., Tang, H., Wang, J., Hu, S., Bai, F., Fan, D. Hybridoma (2005) (2006) [Pubmed]
Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP). Matsuzawa, S., Li, C., Ni, C.Z., Takayama, S., Reed, J.C., Ely, K.R. J. Biol. Chem. (2003) [Pubmed]

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AgaP_AGAP002107	Anopheles gambiae str. PEST
AT1G30070	Arabidopsis thaliana
CACYBP	Bos taurus
CACYBP	Canis lupus familiaris
cacybp	Danio rerio
CG3226	Drosophila melanogaster
CACYBP	Gallus gallus
CACYBP	Macaca mulatta
Cacybp	Mus musculus
Os01g0757500	Oryza sativa Japonica Group
CACYBP	Pan troglodytes
Cacybp	Rattus norvegicus
cacybp	Xenopus (Silurana) tropicalis

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