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Gene Review

SDCBP2  -  syndecan binding protein (syntenin) 2

Homo sapiens

Synonyms: SITAC, SITAC18, ST-2, Syndecan-binding protein 2, Syntenin-2
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Disease relevance of SDCBP2

  • Hyperthermia together with MGBG, DFMO plus ACNU brought about remarkable antiproliferative effects on ST-2 tumor growth, compared to three regimens with MGBG, DFMO plus heat, MGBG, DFMO plus ACNU, as well as ACNU plus heat [1].

High impact information on SDCBP2

  • Surprisingly, these domains target syntenin-2 to nuclear PIP2 pools, in nuclear speckles and nucleoli [2].
  • We report that most PDZ proteins bind weakly to PIP2, but that syntenin-2, the closest homolog of syntenin-1, binds with high affinity to PIP2 via its PDZ domains [2].
  • Depletion of syntenin-2 disrupts the nuclear speckles-PIP2 pattern and affects cell survival and cell division [2].
  • In the present study, we have investigated estrogen effects on osteoblastic and adipocytic differentiation from a mouse bone marrow stromal cell line, ST-2, which had been manipulated to overexpress either human ER alpha (ST2ER alpha) or ER beta (ST2ER beta) [3].
  • Treatment of ST-2 cells with 17beta-E(2) resulted in up-regulation of OPG expression at both the messenger RNA and protein levels [4].

Biological context of SDCBP2


Associations of SDCBP2 with chemical compounds


  1. Enhanced antitumor efficacy with a combination of hyperthermochemotherapy and thermosensitization with polyamine antimetabolites in nude mice. Fujimoto, S., Shrestha, R.D., Ohta, M., Igarashi, K., Endoh, F., Kokubun, M., Koike, S., Togawa, Y., Okui, K. The Japanese journal of surgery. (1987) [Pubmed]
  2. Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. Mortier, E., Wuytens, G., Leenaerts, I., Hannes, F., Heung, M.Y., Degeest, G., David, G., Zimmermann, P. EMBO J. (2005) [Pubmed]
  3. Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta. Okazaki, R., Inoue, D., Shibata, M., Saika, M., Kido, S., Ooka, H., Tomiyama, H., Sakamoto, Y., Matsumoto, T. Endocrinology (2002) [Pubmed]
  4. 17beta-estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-alpha. Saika, M., Inoue, D., Kido, S., Matsumoto, T. Endocrinology (2001) [Pubmed]
  5. Frequent detection of bocavirus DNA in German children with respiratory tract infections. Weissbrich, B., Neske, F., Schubert, J., Tollmann, F., Blath, K., Blessing, K., Kreth, H.W. BMC Infect. Dis. (2006) [Pubmed]
  6. Clonal variability of group B Streptococcus among different groups of carriers in southern Israel. Marchaim, D., Efrati, S., Melamed, R., Gortzak-Uzan, L., Riesenberg, K., Zaidenstein, R., Schlaeffer, F. Eur. J. Clin. Microbiol. Infect. Dis. (2006) [Pubmed]
  7. Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids. Kimura, T., Doi, K. Toxicologic pathology. (1999) [Pubmed]
  8. Comparison of the determination of magnesium by methylthymol blue spectrophotometry and atomic absorption spectrophotometry. Saur, P.M., Zielmann, S., Roth, A., Frank, L., Warneke, G., Ensink, F.B., Radke, A. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. (1994) [Pubmed]
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