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Chemical Compound Review

Asmanex     [(9S,10S,11S,13S,14S,16R,17R)- 9-chloro-17...

Synonyms: Danitin, Elocone, Flumeta, Nasonex, Nosorex, ...
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Disease relevance of Nasonex


High impact information on Nasonex


Chemical compound and disease context of Nasonex


Biological context of Nasonex


Anatomical context of Nasonex


Associations of Nasonex with other chemical compounds


Gene context of Nasonex

  • Within-treatment comparisons suggested that mometasone furoate reduced the antigen-induced late-phase response for IL-6, IL-8, and eosinophils compared with pretreatment [26].
  • CONCLUSION: These results suggest that the clinical activity of mometasone furoate nasal spray in seasonal allergic rhinitis is likely due, in part, to a reduction in the levels of histamine in nasal secretions related to the early phase response, and reductions in IL-6, IL-8, and eosinophils during the late phase response [26].
  • There were increased levels of steady-state mRNA for interleukin-4, interleukin-5, and to a lesser extent, gamma-interferon in the lungs of sensitized mice after ovalbumin challenge and pretreatment with mometasone furoate reduced the steady-state mRNA levels of these cytokines [27].
  • A placebo- and active-controlled randomized trial of prophylactic treatment of seasonal allergic rhinitis with mometasone furoate aqueous nasal spray [28].
  • METHODS: A randomised, double blind, crossover trial of placebo and mometasone furoate (800 microg/day), each given for 6 weeks with a 4 week washout period, was performed in subjects with COPD treated with bronchodilator therapy only [29].

Analytical, diagnostic and therapeutic context of Nasonex


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  2. Subjective and objective assessments in patients with seasonal allergic rhinitis: effects of therapy with mometasone furoate nasal spray. Meltzer, E.O., Jalowayski, A.A., Orgel, H.A., Harris, A.G. J. Allergy Clin. Immunol. (1998) [Pubmed]
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  4. Corticosteroids inhibit rhinovirus-induced intercellular adhesion molecule-1 up-regulation and promoter activation on respiratory epithelial cells. Papi, A., Papadopoulos, N.G., Degitz, K., Holgate, S.T., Johnston, S.L. J. Allergy Clin. Immunol. (2000) [Pubmed]
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  7. Dose-dependent effects of inhaled mometasone furoate on airway function and inflammation after allergen inhalation challenge. Inman, M.D., Watson, R.M., Rerecich, T., Gauvreau, G.M., Lutsky, B.N., Stryszak, P., O'Byrne, P.M. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  8. Inhaled mometasone furoate reduces oral prednisone requirements while improving respiratory function and health-related quality of life in patients with severe persistent asthma. Fish, J.E., Karpel, J.P., Craig, T.J., Bensch, G.W., Noonan, M., Webb, D.R., Silverman, B., Schenkel, E.J., Rooklin, A.R., Ramsdell, J.W., Nathan, R., Leflein, J.G., Grossman, J., Graft, D.F., Gower, R.G., Garay, S.M., Frigas, E., Degraff, A.C., Bronsky, E.A., Bernstein, D.I., Berger, W., Shneyer, L., Nolop, K.B., Harrison, J.E. J. Allergy Clin. Immunol. (2000) [Pubmed]
  9. Mometasone furoate antagonizes AMP-induced bronchoconstriction in patients with mild asthma. Holgate, S.T., Arshad, H., Stryszak, P., Harrison, J.E. J. Allergy Clin. Immunol. (2000) [Pubmed]
  10. A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis. Lumry, W.R. J. Allergy Clin. Immunol. (1999) [Pubmed]
  11. Comparison of once daily mometasone furoate (Nasonex) and fluticasone propionate aqueous nasal sprays for the treatment of perennial rhinitis. The 194-079 Study Group. Mandl, M., Nolop, K., Lutsky, B.N. Ann. Allergy Asthma Immunol. (1997) [Pubmed]
  12. Comparison of mometasone furoate 0.1% cream and hydrocortisone 1.0% cream in the treatment of childhood atopic dermatitis. Vernon, H.J., Lane, A.T., Weston, W. J. Am. Acad. Dermatol. (1991) [Pubmed]
  13. Mometasone furoate 0.1%-salicylic acid 5% ointment versus mometasone furoate 0.1% ointment in the treatment of moderate-to-severe psoriasis: a multicenter study. Koo, J., Cuffie, C.A., Tanner, D.J., Bressinck, R., Cornell, R.C., DeVillez, R.L., Edwards, L., Breneman, D.L., Piacquadio, D.J., Guzzo, C.A., Monroe, E.W. Clinical therapeutics. (1998) [Pubmed]
  14. Effect of mometasone furoate by topical application on allergic rhinitis model in rats. Sugimoto, Y., Ishizawa, K., Saitou, K., Suzuki, G., Tarumi, T., Nakahara, H., Kirino, Y., Kamei, C. Pharmacology (2000) [Pubmed]
  15. Human receptor kinetics, tissue binding affinity, and stability of mometasone furoate. Valotis, A., Neukam, K., Elert, O., Högger, P. Journal of pharmaceutical sciences. (2004) [Pubmed]
  16. Once-daily evening administration of mometasone furoate in asthma treatment initiation. Bensch, G.W., Prenner, B., Berkowitz, R., Galant, S., Ramsdell, J., Lutsky, B. Ann. Allergy Asthma Immunol. (2006) [Pubmed]
  17. Effects of intranasal corticosteroids on adrenal, bone, and blood markers of systemic activity in allergic rhinitis. Wilson, A.M., Sims, E.J., McFarlane, L.C., Lipworth, B.J. J. Allergy Clin. Immunol. (1998) [Pubmed]
  18. Relative lack of systemic effects of mometasone furoate on Langerhans cells of mice after topical administration as compared with other glucocorticosteroids. Belsito, D.V., Baer, R.L., Schultz, J.M., Thorbecke, G.J. J. Invest. Dermatol. (1988) [Pubmed]
  19. Binding affinities of mometasone furoate and related compounds including its metabolites for the glucocorticoid receptor of rat skin tissue. Isogai, M., Shimizu, H., Esumi, Y., Terasawa, T., Okada, T., Sugeno, K. J. Steroid Biochem. Mol. Biol. (1993) [Pubmed]
  20. Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. Kagoshima, M., Wilcke, T., Ito, K., Tsaprouni, L., Barnes, P.J., Punchard, N., Adcock, I.M. Eur. J. Pharmacol. (2001) [Pubmed]
  21. Concentration-dependent effects of mometasone furoate and dexamethasone on foetal lung fibroblast functions involved in airway inflammation and remodeling. Sabatini, F., Silvestri, M., Sale, R., Serpero, L., Giuliani, M., Scarso, L., Favini, P., Rossi, G.A. Pulmonary pharmacology & therapeutics. (2003) [Pubmed]
  22. Corticosteroids in the treatment of pediatric allergic rhinitis. Scadding, G.K. J. Allergy Clin. Immunol. (2001) [Pubmed]
  23. An in vitro comparison of commonly used topical glucocorticoid preparations. Stellato, C., Atsuta, J., Bickel, C.A., Schleimer, R.P. J. Allergy Clin. Immunol. (1999) [Pubmed]
  24. Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes. Madauss, K.P., Deng, S.J., Austin, R.J., Lambert, M.H., McLay, I., Pritchard, J., Short, S.A., Stewart, E.L., Uings, I.J., Williams, S.P. J. Med. Chem. (2004) [Pubmed]
  25. A review of the pharmacology and pharmacokinetics of inhaled fluticasone propionate and mometasone furoate. Crim, C., Pierre, L.N., Daley-Yates, P.T. Clinical therapeutics. (2001) [Pubmed]
  26. Effect of mometasone furoate on early and late phase inflammation in patients with seasonal allergic rhinitis. Frieri, M., Therattil, J., Chavarria, V., Cosachov, J., Kumar, N.S., Wang, S.F., Sansone, G., Etzel, J., Dellevecchia, D., Zitt, M., Mesarina-Wicki, B., Nolop, K.B. Ann. Allergy Asthma Immunol. (1998) [Pubmed]
  27. Anti-inflammatory activity of inhaled mometasone furoate in allergic mice. Chapman, R.W., Sehring, S.J., Garlisi, C.G., Falcone, A., Kung, T.T., Stelts, D., Minnicozzi, M., Jones, H., Umland, S., Egan, R.W., Kreutner, W. Arzneimittel-Forschung. (1998) [Pubmed]
  28. A placebo- and active-controlled randomized trial of prophylactic treatment of seasonal allergic rhinitis with mometasone furoate aqueous nasal spray. Graft, D., Aaronson, D., Chervinsky, P., Kaiser, H., Melamed, J., Pedinoff, A., Rosen, J.P., Schenkel, E.J., Vandewalker, M.L., Keim, A., Jensen, P.K., Nolop, K., Mesarina-Wicki, B. J. Allergy Clin. Immunol. (1996) [Pubmed]
  29. Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Brightling, C.E., McKenna, S., Hargadon, B., Birring, S., Green, R., Siva, R., Berry, M., Parker, D., Monteiro, W., Pavord, I.D., Bradding, P. Thorax (2005) [Pubmed]
  30. Inhaled mometasone furoate: a review of its use in adults and adolescents with persistent asthma. Sharpe, M., Jarvis, B. Drugs (2001) [Pubmed]
  31. Mometasone furoate has minimal effects on the hypothalamic-pituitary-adrenal axis when delivered at high doses. Affrime, M.B., Kosoglou, T., Thonoor, C.M., Flannery, B.E., Herron, J.M. Chest (2000) [Pubmed]
  32. An evaluation of short-term corticosteroid response in perennial allergic rhinitis using histamine and adenosine monophosphate nasal challenge. Wilson, A.M., Sims, E.J., Orr, L.C., Robb, F., Lipworth, B.J. British journal of clinical pharmacology. (2003) [Pubmed]
  33. Bioavailability and metabolism of mometasone furoate following administration by metered-dose and dry-powder inhalers in healthy human volunteers. Affrime, M.B., Cuss, F., Padhi, D., Wirth, M., Pai, S., Clement, R.P., Lim, J., Kantesaria, B., Alton, K., Cayen, M.N. Journal of clinical pharmacology. (2000) [Pubmed]
  34. An unusual rearrangement product formed during production of mometasone furoate (Sch 32088). Puar, M.S., Thompson, P.A., Ruggeri, M., Beiner, D., McPhail, A.T. Steroids (1995) [Pubmed]
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