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Gene Review

plcA  -  1-phosphatidylinositol phosphodiesterase

Listeria monocytogenes serotype 4b str. F2365

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Disease relevance of plcA


High impact information on plcA

  • The system was successfully tested using the promoter of the inducible virulence gene plcA [2].
  • Although plcA expression is known to depend on PrfA, a prfA promoter-lacZ fusion was highly expressed both inside and outside cells [3].
  • Transcriptional hlyA and plcA fusions to luxAB were used to monitor virulent gene expression in the presence of various disaccharides [4].
  • Significantly decreased transcription of the plcA gene, encoding a phospholipase C involved in vacuolar escape and cell-to-cell spread, was observed in acid-adapted bacteria [5].
  • The remaining hemolytic L. monocytogenes isolates lacking the plcA gene and PI-PLC assay activity were, however, non-pathogenic via mice and chick-embryo inoculation tests, in spite of having the hlyA gene [6].

Biological context of plcA

  • Increased plcA transcript levels, which were similar in both host cell vacuole and cytosol, were associated with increases in both prfA expression and PrfA activity. qRT-PCR assays were designed to measure expression of prfA from each of its three promoter regions [7].

Analytical, diagnostic and therapeutic context of plcA

  • This particular strain was revealed to be avirulent and defective in hlyA and plcA in PCR amplification [8].


  1. The bvr locus of Listeria monocytogenes mediates virulence gene repression by beta-glucosides. Brehm, K., Ripio, M.T., Kreft, J., Vázquez-Boland, J.A. J. Bacteriol. (1999) [Pubmed]
  2. The use of listeriolysin to identify in vivo induced genes in the gram-positive intracellular pathogen Listeria monocytogenes. Gahan, C.G., Hill, C. Mol. Microbiol. (2000) [Pubmed]
  3. Five Listeria monocytogenes genes preferentially expressed in infected mammalian cells: plcA, purH, purD, pyrE and an arginine ABC transporter gene, arpJ. Klarsfeld, A.D., Goossens, P.L., Cossart, P. Mol. Microbiol. (1994) [Pubmed]
  4. Expression of listeriolysin and phosphatidylinositol-specific phospholipase C is repressed by the plant-derived molecule cellobiose in Listeria monocytogenes. Park, S.F., Kroll, R.G. Mol. Microbiol. (1993) [Pubmed]
  5. Effect of acid adaptation on the fate of Listeria monocytogenes in THP-1 human macrophages activated by gamma interferon. Conte, M.P., Petrone, G., Di Biase, A.M., Longhi, C., Penta, M., Tinari, A., Superti, F., Fabozzi, G., Visca, P., Seganti, L. Infect. Immun. (2002) [Pubmed]
  6. Isolation of Listeria monocytogenes from buffaloes with reproductive disorders and its confirmation by polymerase chain reaction. Shakuntala, I., Malik, S.V., Barbuddhe, S.B., Rawool, D.B. Vet. Microbiol. (2006) [Pubmed]
  7. Contributions of Listeria monocytogenes sigmaB and PrfA to expression of virulence and stress response genes during extra- and intracellular growth. Kazmierczak, M.J., Wiedmann, M., Boor, K.J. Microbiology (Reading, Engl.) (2006) [Pubmed]
  8. Correlation between the presence of virulence-associated genes as determined by PCR and actual virulence to mice in various strains of Listeria spp. Nishibori, T., Cooray, K., Xiong, H., Kawamura, I., Fujita, M., Mitsuyama, M. Microbiol. Immunol. (1995) [Pubmed]
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