Gene Review:
DCT - dopachrome tautomerase
Homo sapiens
Synonyms:
DT, L-dopachrome Delta-isomerase, L-dopachrome tautomerase, TRP-2, TRP2, ...
- Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. Lupetti, R., Pisarra, P., Verrecchia, A., Farina, C., Nicolini, G., Anichini, A., Bordignon, C., Sensi, M., Parmiani, G., Traversari, C. J. Exp. Med. (1998)
- Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. Yokoyama, K., Yasumoto, K., Suzuki, H., Shibahara, S. J. Biol. Chem. (1994)
- Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma. Udono, T., Takahashi, K., Yasumoto , K., Yoshizawa, M., Takeda, K., Abe, T., Tamai, M., Shibahara, S. Exp. Eye Res. (2001)
- Role of neurofibromin in modulation of expression of the tyrosinase-related protein 2 gene. Suzuki, H., Takahashi, K., Yasumoto, K., Amae, S., Yoshizawa, M., Fuse, N., Shibahara, S. J. Biochem. (1998)
- TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content. Pak, B.J., Li, Q., Kerbel, R.S., Ben-David, Y. Melanoma Res. (2000)
- Central effects of beta-adrenoceptor antagonists. Salem, S.A., McDevitt, D.G. Clin. Pharmacol. Ther. (1983)
- Efficacy of short mental tests in the detection of mental impairment in old age. Engedal, K., Haugen, P., Gilje, K., Laake, P. Comprehensive gerontology. Section A, Clinical and laboratory sciences. (1988)
- Renal magnesium handling and its hormonal control. de Rouffignac, C., Quamme, G. Physiol. Rev. (1994)
- Coupling and uncoupling of tumor immunity and autoimmunity. Bowne, W.B., Srinivasan, R., Wolchok, J.D., Hawkins, W.G., Blachere, N.E., Dyall, R., Lewis, J.J., Houghton, A.N. J. Exp. Med. (1999)
- Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. Bloom, M.B., Perry-Lalley, D., Robbins, P.F., Li, Y., el-Gamil, M., Rosenberg, S.A., Yang, J.C. J. Exp. Med. (1997)
- Human melanocytes and melanomas express novel mRNA isoforms of the tyrosinase-related protein-2/DOPAchrome tautomerase gene: molecular and functional characterization. Pisarra, P., Lupetti, R., Palumbo, A., Napolitano, A., Prota, G., Parmiani, G., Anichini, A., Sensi, M. J. Invest. Dermatol. (2000)
- Sulfur-containing amino acids decrease cisplatin cytotoxicity and uptake in renal tubule epithelial cell lines. Kröning, R., Lichtenstein, A.K., Nagami, G.T. Cancer Chemother. Pharmacol. (2000)
- A phase II study of dose-dense docetaxel and mitoxantrone in the treatment of patients with high-risk metastatic breast cancer. König, E., Kurbacher, C., Schwonzen, M., Breidenbach, M., Mallmann, P. Anticancer Drugs (2002)
- Tyrosinase-related protein 2 as a mediator of melanoma specific resistance to cis-diamminedichloroplatinum(II): therapeutic implications. Chu, W., Pak, B.J., Bani, M.R., Kapoor, M., Lu, S.J., Tamir, A., Kerbel, R.S., Ben-David, Y. Oncogene (2000)
- OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium. Takeda, K., Yokoyama, S., Yasumoto, K., Saito, H., Udono, T., Takahashi, K., Shibahara, S. Biochem. Biophys. Res. Commun. (2003)
- Comparison of the melanogenesis in human black and light brown melanocytes. Maeda, K., Yokokawa, Y., Hatao, M., Naganuma, M., Tomita, Y. J. Dermatol. Sci. (1997)
- Regulation of tyrosinase-related protein-2 (TYRP2) in human melanocytes: relationship to growth and morphology. Fang, D., Kute, T., Setaluri, V. Pigment Cell Res. (2001)
- Differential regulation of melanosomal proteins after hinokitiol treatment. Choi, Y.G., Bae, E.J., Kim, D.S., Park, S.H., Kwon, S.B., Na, J.I., Park, K.C. J. Dermatol. Sci. (2006)
- Effect of arbutin on melanogenic proteins in human melanocytes. Chakraborty, A.K., Funasaka, Y., Komoto, M., Ichihashi, M. Pigment Cell Res. (1998)
- Enhanced survival associated with vitiligo expression during maintenance biotherapy for metastatic melanoma. Boasberg, P.D., Hoon, D.S., Piro, L.D., Martin, M.A., Fujimoto, A., Kristedja, T.S., Bhachu, S., Ye, X., Deck, R.R., O'Day, S.J. J. Invest. Dermatol. (2006)
- Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells. Rad, H.H., Yamashita, T., Jin, H.Y., Hirosaki, K., Wakamatsu, K., Ito, S., Jimbow, K. Exp. Cell Res. (2004)
- RT-PCR detection of tyrosinase, gp100, MART1/Melan-A, and TRP-2 gene transcripts in peripheral blood of melanoma patients. Samija, M., Juretić, A., Solarić, M., Samija, I., Bingulac-Popović, J., Grahovac, B., Stanec, M., Oresić, V. Croat. Med. J. (2001)
- Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. Khong, H.T., Rosenberg, S.A. J. Immunol. (2002)
- Levels of dopachrome tautomerase in human melanocytes cultured in vitro. Bernd, A., Ramirez-Bosca, A., Kippenberger, S., Martinez-Liarte, J.H., Holzmann, H., Solano, F. Melanoma Res. (1994)
- Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy. Liu, G., Akasaki, Y., Khong, H.T., Wheeler, C.J., Das, A., Black, K.L., Yu, J.S. Oncogene (2005)