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Gene Review:

DCT - dopachrome tautomerase

Gallus gallus

Austin, L.M. et al., April, C.S. et al., McCormick, A.A. et al.

April, Jackson, Kidson,

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High impact information on DCT

SL autoantibodies recognize a chicken melanocyte protein that is different from that of tyrosinase or the candidate chicken TRP-2 [1].
We have tested a model foreign antigen target-the chicken ovalbumin-derived CTL peptide (Ova peptide), as well as mouse melanoma-associated CTL epitopes p15e and tyrosinase-related protein 2 (Trp2) peptides that are self-antigen targets [2].
Genomic Southern blot hybridisation analysis suggests that the chicken DCT gene consists of several introns and spans between 15 and 30kb of the chicken genome [3].
We have cloned and sequenced a chicken cDNA encoding an l-DOPAchrome tautomerase (DCT) from an embryonic melanocyte cDNA library [3].
Northern blot hybridisation analysis reveals a DCT transcript of 3.5kb in RNA from the retinal pigment epithelium (RPE) of chick embryos [3].

References

Mammalian tyrosinase-related protein-1 is recognized by autoantibodies from vitiliginous Smyth chickens. An avian model for human vitiligo. Austin, L.M., Boissy, R.E. Am. J. Pathol. (1995) [Pubmed]
Chemical Conjugate TMV-Peptide Bivalent Fusion Vaccines Improve Cellular Immunity and Tumor Protection. McCormick, A.A., Corbo, T.A., Wykoff-Clary, S., Palmer, K.E., Pogue, G.P. Bioconjug. Chem. (2006) [Pubmed]
Molecular cloning and sequence analysis of a chicken cDNA encoding tyrosinase-related protein-2/DOPAchrome tautomerase. April, C.S., Jackson, I.J., Kidson, S.H. Gene (1998) [Pubmed]

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