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Gene Review:

MET - MET proto-oncogene, receptor tyrosine kinase

Bos taurus

Synonyms: HGFR, c-met

Parrott, J.A. et al., Murakami, S. et al., Nakagami, H. et al., Uchida, D. et al., Schulte, K.M. et al.

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High impact information on c-met

We detected the expression of c-met (HGF receptor) mRNA in all of the cancer cells, but not in human gingival fibroblasts (GF) [1].
Reverse transcription-polymerase chain reaction (RT-PCR) analysis was used to examine HGF expression in theca cells and the HGF receptor (HGFR or c-met) in granulosa cells [2].
RT-PCR revealed that mRNA of HGF is expressed only in stromal cells, and that c-met mRNA is expressed in both stromal and epithelial cells [3].
The biological and clinical significance of HGF and its receptor c-met in the thyroid is currently under study [4].

Anatomical context of c-met

Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells [5].

References

Role of HGF/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance. Uchida, D., Kawamata, H., Omotehara, F., Nakashiro Ki, n.u.l.l., Kimura-Yanagawa, T., Hino, S., Begum, N.M., Hoque, M.O., Yoshida, H., Sato, M., Fujimori, T. Int. J. Cancer (2001) [Pubmed]
Developmental and hormonal regulation of hepatocyte growth factor expression and action in the bovine ovarian follicle. Parrott, J.A., Skinner, M.K. Biol. Reprod. (1998) [Pubmed]
Expression and action of hepatocyte growth factor in bovine endometrial stromal and epithelial cells in vitro. Murakami, S., Miyamoto, Y., Fujiwara, C., Takeuchi, S., Takahashi, S., Okuda, K. Mol. Reprod. Dev. (2001) [Pubmed]
Regulation of the HGF-receptor c-met in the thyroid gland. Schulte, K.M., Antoch, G., Ellrichmann, M., Finken-Eigen, M., Köhrer, K., Simon, D., Goretzki, P.E., Röher, H.D. Exp. Clin. Endocrinol. Diabetes (1998) [Pubmed]
Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells. Nakagami, H., Morishita, R., Nishikawa, T., Shimizu, H., Iguchi, S., Matsumoto, K., Nakamura, T., Kaneda, Y., Ogihara, T. Hypertens. Res. (2004) [Pubmed]

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MET	Canis lupus familiaris
met	Danio rerio
MET	Gallus gallus
MET	Homo sapiens
MET	Macaca mulatta
Met	Mus musculus
MET	Pan troglodytes
Met	Rattus norvegicus
met	Xenopus (Silurana) tropicalis

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