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CSF3  -  colony stimulating factor 3 (granulocyte)

Bos taurus

 
 
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Disease relevance of CSF3

  • In the second study, systemic administration of GCSF increased peripheral blood as well as milk neutrophil populations, which afforded some protection against Staphylococcus aureus challenge [1].
 

High impact information on CSF3

  • The crystal structures of recombinant canine and bovine granulocyte colony stimulating factor (G-CSF) have been determined by X-ray crystallography, using molecular replacement with recombinant human G-CSF as a model [2].
  • G-CSF is a member of the cytokine family of glycoproteins that stimulate the differentiation and proliferation of blood cells [2].
  • On the basis of this probability function as well as a comparison of G-CSF to the crystal structure of human growth hormone (hGH) complexed with the extracellular domain of the human growth hormone receptor (hGHbp), residues that contribute to potential G-CSF receptor binding sites are identified [2].
  • Human, bovine and canine G-CSF all have a molecular mass of about 19 kDa and share an amino acid sequence identity of about 80% [2].
  • The maximal response was observed when neutrophils were incubated with both cytokines together, at concentrations of 200 ng/ml for G-CSF and 400 ng/ml for IL-8 [3].
 

Biological context of CSF3

 

Anatomical context of CSF3

 

Regulatory relationships of CSF3

 

Analytical, diagnostic and therapeutic context of CSF3

References

  1. Effect of cytokines on bovine mammary gland immunity. Nickerson, S.C. SAAS Bull. Biochem. Biotechnol. (1991) [Pubmed]
  2. Crystal structure of canine and bovine granulocyte-colony stimulating factor (G-CSF). Lovejoy, B., Cascio, D., Eisenberg, D. J. Mol. Biol. (1993) [Pubmed]
  3. Effect of interleukin-8 and granulocyte colony-stimulating factor on priming and activation of bovine neutrophils. Mitchell, G.B., Albright, B.N., Caswell, J.L. Infect. Immun. (2003) [Pubmed]
  4. Cloning, sequencing, and analysis of cDNA encoding bovine granulocyte-colony stimulating factor. Heidari, M., Kehrli, M.E. Vet. Immunol. Immunopathol. (2000) [Pubmed]
  5. Macrophage development: IV. Effects of blood factors on macrophages from prenatal rat lung cultures. Sorokin, S.P., McNelly, N.A., Hoyt, R.F. Anat. Rec. (1992) [Pubmed]
 
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