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Gene Review

CXCL8  -  chemokine (C-X-C motif) ligand 8

Bos taurus

Synonyms: IL-8, IL8
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Disease relevance of IL8


High impact information on IL8

  • These results indicated that IL-8 participated in the impairment of renal functions in experimental acute immune complex-mediated glomerulonephritis through activating as well as recruiting neutrophils [5].
  • Anti-IL-8 antibody treatment decreased the number of neutrophils in glomeruli by 40% and dramatically prevented the fusion of epithelial cell foot process [5].
  • Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis [5].
  • Enhanced SEMA5A induces expression of at least nine genes related to the host's immune response, including TNF-alpha and IL-8 [6].
  • The combination of RA and IFN-alpha also acted synergistically on endothelial cells by reducing their responsiveness to both interleukin-8 and tumor conditioned media [7].

Chemical compound and disease context of IL8


Biological context of IL8

  • Based on the breadth of germplasm in bovine diversity panel, the five haplotype structures for IL8 are estimated to represent >98% of those present in these DNA segments in commercial populations of U.S. beef cattle [1].
  • Seven single-nucleotide polymorphism (SNP) markers were identified by sequencing two IL8 DNA segments amplified from the panel of 17 popular cattle breeds (MARC beef cattle diversity panel, version 2.1) [1].
  • In the present study, we determined the nucleotide sequence for bovine IL-8 cDNA [2].
  • The amino acid sequence encoded by this cDNA shares 76 and 87% homology with the human and swine IL-8 proteins, respectively [2].
  • IL-8 encodes a proinflammatory cytokine that plays a central role in cell-mediated immunity by attracting and activating neutrophils in the early stages of host defense against bacterial invasion [1].

Anatomical context of IL8


Associations of IL8 with chemical compounds

  • Neutrophil adhesion to ECMs altered responses to PAF and IL-8, although some functions were more responsive to modulation [15].
  • Microparticles prepared from either chitosan or starch microparticles, applied apically, induced the basolateral release of IL-6 and IL-8 from polarized Calu-3 cells [16].
  • RESULTS: Incubation with TNF-alpha, IL-8, PAF, and LPS primed neutrophils for oxygen radical release but caused minimal oxygen radical release by themselves [17].
  • CpG-DNA-induced IL-8 mRNA expression and release was also blocked by the NO synthase inhibitor Nomega-nitro-L-arginine methyl ester [18].
  • Recent studies indicate that peroxynitrite (ONOO-) may function as an intracellular signal for the production of IL-8, one of the key regulators of leukocyte trafficking in inflammation [18].

Regulatory relationships of IL8


Other interactions of IL8


Analytical, diagnostic and therapeutic context of IL8


  1. Interleukin-8 haplotype structure from nucleotide sequence variation in commercial populations of U.S. beef cattle. Heaton, M.P., Chitko-McKnown, C.G., Grosse, W.M., Keele, J.W., Keen, J.E., Laegreid, W.W. Mamm. Genome (2001) [Pubmed]
  2. Molecular cloning and expression of bovine interleukin-8. Morsey, M.A., Popowych, Y., Kowalski, J., Gerlach, G., Godson, D., Campos, M., Babiuk, L.A. Microb. Pathog. (1996) [Pubmed]
  3. A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp paratuberculosis. Weiss, D.J., Evanson, O.A., de Souza, C., Abrahamsen, M.S. Am. J. Vet. Res. (2005) [Pubmed]
  4. Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation. Singh, B., Pearce, J.W., Gamage, L.N., Janardhan, K., Caldwell, S. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  5. Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis. Wada, T., Tomosugi, N., Naito, T., Yokoyama, H., Kobayashi, K., Harada, A., Mukaida, N., Matsushima, K. J. Exp. Med. (1994) [Pubmed]
  6. Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Sugimoto, M., Fujikawa, A., Womack, J.E., Sugimoto, Y. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Retinoic acid and interferon alpha act synergistically as antiangiogenic and antitumor agents against human head and neck squamous cell carcinoma. Lingen, M.W., Polverini, P.J., Bouck, N.P. Cancer Res. (1998) [Pubmed]
  8. In vitro expression of tumor necrosis factor-alpha, interleukin 1beta, and interleukin 8 mRNA by bovine macrophages following exposure to Porphyromonas levii. Walter, M.R., Morck, D.W. Can. J. Vet. Res. (2002) [Pubmed]
  9. Effect of interleukin-8 on glomerular sulfated compounds and albuminuria. Garin, E.H., West, L., Zheng, W. Pediatr. Nephrol. (1997) [Pubmed]
  10. Tilmicosin does not inhibit interleukin-8 gene expression in the bovine lung experimentally infected with Mannheimia (Pasteurella) haemolytica. Goubau, S., Morck, D.W., Buret, A. Can. J. Vet. Res. (2000) [Pubmed]
  11. Suppression of elevated plasma interleukin-8 levels due to total ischemia and reperfusion of the small intestine by luminal perfusion with fetal bovine serum. Chen, Y., Hung, W.T., Chen, S.M., Tseng, S.H. Pediatr. Surg. Int. (2002) [Pubmed]
  12. Cytokine gene expression in peripheral blood mononuclear cells and tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis: evidence for an inherent proinflammatory gene expression pattern. Coussens, P.M., Verman, N., Coussens, M.A., Elftman, M.D., McNulty, A.M. Infect. Immun. (2004) [Pubmed]
  13. Lysophosphatidylcholine induces the production of IL-1beta by human monocytes. Liu-Wu, Y., Hurt-Camejo, E., Wiklund, O. Atherosclerosis (1998) [Pubmed]
  14. Cytotoxicity of cytokines in cerebral microvascular endothelial cell. Kimura, H., Gules, I., Meguro, T., Zhang, J.H. Brain Res. (2003) [Pubmed]
  15. Adhesion to extracellular matrix proteins modulates bovine neutrophil responses to inflammatory mediators. Borgquist, J.D., Quinn, M.T., Swain, S.D. J. Leukoc. Biol. (2002) [Pubmed]
  16. In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery. Witschi, C., Mrsny, R.J. Pharm. Res. (1999) [Pubmed]
  17. Role of inflammatory mediators in priming, activation, and deformability of bovine neutrophils. McClenahan, D., Fagliari, J., Evanson, O., Weiss, D. Am. J. Vet. Res. (2000) [Pubmed]
  18. Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils. József, L., Khreiss, T., El Kebir, D., Filep, J.G. J. Immunol. (2006) [Pubmed]
  19. Effect of interleukin-8 and granulocyte colony-stimulating factor on priming and activation of bovine neutrophils. Mitchell, G.B., Albright, B.N., Caswell, J.L. Infect. Immun. (2003) [Pubmed]
  20. Identification and genetic mapping of bovine chemokine genes expressed in epithelial cells. Heaton, M.P., Laegreid, W.W., Beattie, C.W., Smith, T.P., Kappes, S.M. Mamm. Genome (1999) [Pubmed]
  21. Cryopreserved bovine mammary cells to model epithelial response to infection. Wellnitz, O., Kerr, D.E. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  22. Coordinated expression of tracheal antimicrobial peptide and inflammatory-response elements in the lungs of neonatal calves with acute bacterial pneumonia. Caverly, J.M., Diamond, G., Gallup, J.M., Brogden, K.A., Dixon, R.A., Ackermann, M.R. Infect. Immun. (2003) [Pubmed]
  23. Torsion-angle molecular dynamics as a new efficient tool for NMR structure calculation. Stein, E.G., Rice, L.M., Brünger, A.T. J. Magn. Reson. (1997) [Pubmed]
  24. Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. Herzog, H., Hort, Y.J., Shine, J., Selbie, L.A. DNA Cell Biol. (1993) [Pubmed]
  25. Quantitation of the cytokines TNF-alpha, IL-8 and IL-10 in bovine milk using real-time TaqMan PCR. Peli, A., Luciani, A., De Santis, P., Polci, A., Britti, D. Vet. Res. Commun. (2004) [Pubmed]
  26. Cytokine profiles following interaction between bovine alveolar macrophages and Pasteurella haemolytica. Morsey, M.A., Van-Kessel, A.G., Mori, Y., Popowych, Y., Godson, D., Campos, M., Babiuk, L.A. Microb. Pathog. (1999) [Pubmed]
  27. Cytokine response of bovine mammary gland epithelial cells to Escherichia coli, coliform culture filtrate, or lipopolysaccharide. McClenahan, D.J., Sotos, J.P., Czuprynski, C.J. Am. J. Vet. Res. (2005) [Pubmed]
  28. Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments. Higgins, G.T., Wang, J.H., Dockery, P., Cleary, P.E., Redmond, H.P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
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