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Gene Review

HCRT  -  hypocretin (orexin) neuropeptide precursor

Bos taurus

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Psychiatry related information on HCRT

  • Orexin-A has recently been identified as a new hypothalamic peptide working as a mediator in the regulation of feeding behavior and sleep control [1].

High impact information on HCRT

  • These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain [2].
  • These findings suggest that orexin-A activates tyrosine hydroxylase and then stimulates catecholamine synthesis, probably via activation of the OX(1)R-protein kinase C pathway in adrenal medullary cells [1].
  • To determine the role of orexin-A in peripheral metabolic processes, we examined direct effects of orexin-A on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells [1].
  • 4 beta-Phorbol-12 beta-myristate-13 alpha-acetate, an activator of protein kinase C, did not enhance the stimulatory effects of orexin-A on tyrosine hydroxylase activity, while H-7 and staurosporine, inhibitors of protein kinase C, nullified the effects of orexin-A [1].
  • Orexin-A (100 pM) potentiated the stimulatory effects of acetylcholine (0.3 mM) on 14C-catecholamine synthesis [1].

Biological context of HCRT


Anatomical context of HCRT


Associations of HCRT with chemical compounds


Other interactions of HCRT


Analytical, diagnostic and therapeutic context of HCRT


  1. Stimulation of catecholamine synthesis by orexin-A in bovine adrenal medullary cells through orexin receptor 1. Kawada, Y., Ueno, S., Asayama, K., Tsutsui, M., Utsunomiya, K., Toyohira, Y., Morisada, N., Tanaka, K., Shirahata, A., Yanagihara, N. Biochem. Pharmacol. (2003) [Pubmed]
  2. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S., Arch, J.R., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J., Yanagisawa, M. Cell (1998) [Pubmed]
  3. Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. Furuse, M., Ando, R., Bungo, T., Ao, R., Shimojo, M., Masuda, Y. Br. Poult. Sci. (1999) [Pubmed]
  4. The physiological role of orexins. Martynska, L., Wolinska-Witort, E., Chmielowska, M., Bik, W., Baranowska, B. Neuro Endocrinol. Lett. (2005) [Pubmed]
  5. Requirement of intact disulfide bonds in orexin-A-induced stimulation of gastric acid secretion that is mediated by OX1 receptor activation. Okumura, T., Takeuchi, S., Motomura, W., Yamada, H., Egashira Si, S., Asahi, S., Kanatani, A., Ihara, M., Kohgo, Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Radioimmunoassay for orexin A. Mitsuma, T., Hirooka, Y., Kayama, M., Mori, Y., Yokoi, Y., Rhue, N., Ping, J., Izumi, M., Ikai, R., Adachi, K., Nogimori, T. Life Sci. (2000) [Pubmed]
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