The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

RPE65  -  retinal pigment epithelium-specific...

Bos taurus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of RPE65

  • The identification of RPE65 as the visual cycle target for the retinoic acids makes it feasible to develop useful drugs to treat retinal and macular degeneration while avoiding the substantial side effects of the retinoic acids [1].
  • It is shown here by using a quantitative fluorescence technique, that Accutane (13-cis-retinoic acid), a drug used in the treatment of acne but that causes night blindness, binds to RPE65 with a K(D) of 195 nM [1].
  • METHODS: Rats of four inbred strains (Lewis, Brown Norway, Fischer, and SHR) were immunized with native or recombinant bovine RPE65, or with S-antigen (S-Ag), emulsified with complete Freund adjuvant, and treated simultaneously with killed Bordetella pertussis bacteria, as indicated [2].
 

High impact information on RPE65

 

Biological context of RPE65

  • We compared the levels of translation products and mRNA stability among RPE65 transcripts containing deletions of the 5'- and 3'-UTRs [5].
 

Anatomical context of RPE65

 

Associations of RPE65 with chemical compounds

 

Analytical, diagnostic and therapeutic context of RPE65

References

  1. The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration. Gollapalli, D.R., Rando, R.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. RPE65 is highly uveitogenic in rats. Ham, D.I., Gentleman, S., Chan, C.C., McDowell, J.H., Redmond, T.M., Gery, I. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  3. A palmitoylation switch mechanism in the regulation of the visual cycle. Xue, L., Gollapalli, D.R., Maiti, P., Jahng, W.J., Rando, R.R. Cell (2004) [Pubmed]
  4. Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Maiti, P., Kong, J., Kim, S.R., Sparrow, J.R., Allikmets, R., Rando, R.R. Biochemistry (2006) [Pubmed]
  5. Role of the 3'-untranslated region of RPE65 mRNA in the translational regulation of the RPE65 gene: identification of a specific translation inhibitory element. Liu, S.Y., Redmond, T.M. Arch. Biochem. Biophys. (1998) [Pubmed]
  6. A cleavable affinity biotinylating agent reveals a retinoid binding role for RPE65. Jahng, W.J., David, C., Nesnas, N., Nakanishi, K., Rando, R.R. Biochemistry (2003) [Pubmed]
  7. Lack of effect of RPE65 removal on the enzymatic processing of all-trans-retinol into 11-cis-retinol in vitro. Choo, D.W., Cheung, E., Rando, R.R. FEBS Lett. (1998) [Pubmed]
  8. Identification of the RPE65 protein in mammalian cone photoreceptors. Znoiko, S.L., Crouch, R.K., Moiseyev, G., Ma, J.X. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  9. RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters. Gollapalli, D.R., Maiti, P., Rando, R.R. Biochemistry (2003) [Pubmed]
 
WikiGenes - Universities