High impact information on SLC6A2

• The plasma membrane norepinephrine transporter was apparently present in a separate type of vesicle, but this requires further study [1].
• Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells [2].
• Inhibition of the norepinephrine transporter function in cultured bovine adrenal medullary cells by bisphenol A [3].
• Tramadol inhibits norepinephrine transporter function at desipramine-binding sites in cultured bovine adrenal medullary cells [4].
• Alphaxalone, a neurosteroid anesthetic, inhibits norepinephrine transporter function in cultured bovine adrenal medullary cells [5].

Biological context of SLC6A2

• Identification and functional characterization of the novel isoforms of bovine norepinephrine transporter produced by alternative splicing [6].
• The nucleotide and deduced amino acid sequence shows a high level of homology to the human and the bovine norepinephrine transporter and less homology to the rat dopamine transporter (rDAT) [7].
• We studied the effects of alphaxalone, a neurosteroid anesthetic, on norepinephrine transporter (NET) function in cultured bovine adrenal medullary cells and the effect of a bolus injection of alphaxalone on blood pressure and serum norepinephrine (NE) levels in anesthetized rats [5].

Anatomical context of SLC6A2

• The inhibition of norepinephrine transporter (NET) in the sympathetic nervous system may partly account for the stimulatory actions of pancuronium [8].
• To study the effects of tramadol on norepinephrine transporter (NET) function, we assayed the effect of tramadol on [3H]-norepinephrine ([3H]-NE) uptake and [3H]-desipramine binding to plasma membranes isolated from bovine adrenal medulla [4].

Associations of SLC6A2 with chemical compounds

• Pancuronium may affect the sympathetic nervous system by inhibiting the activity of the presynaptic norepinephrine transporter at clinically relevant concentrations [8].
• We hypothesized that the HED compounds would be most potent at the norepinephrine transporter (NET) compared to the serotonin or dopamine transporters and that the 1R diastereomers would be more effective than 1S diastereomers [9].

References