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Gene Review

Slc6a2  -  solute carrier family 6 (neurotransmitter...

Mus musculus

Synonyms: NE transporter, NE-T, NET, Norepinephrine transporter, Slc6a5, ...
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Disease relevance of Slc6a2


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Biological context of Slc6a2


Anatomical context of Slc6a2


Associations of Slc6a2 with chemical compounds


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Analytical, diagnostic and therapeutic context of Slc6a2


  1. Norepinephrine transporter-deficient mice exhibit excessive tachycardia and elevated blood pressure with wakefulness and activity. Keller, N.R., Diedrich, A., Appalsamy, M., Tuntrakool, S., Lonce, S., Finney, C., Caron, M.G., Robertson, D. Circulation (2004) [Pubmed]
  2. Differential expression of transporters for norepinephrine and glutamate in wild type, variant, and WNT1-expressing PC12 cells. Ramachandran, B., Houben, K., Rozenberg, Y.Y., Haigh, J.R., Varpetian, A., Howard, B.D. J. Biol. Chem. (1993) [Pubmed]
  3. Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension. Keller, N.R., Diedrich, A., Appalsamy, M., Miller, L.C., Caron, M.G., McDonald, M.P., Shelton, R.C., Blakely, R.D., Robertson, D. Neuroscience (2006) [Pubmed]
  4. Reduced 125I-meta-iodobenzylguanidine uptake and norepinephrine transporter density in the hearts of mice with MPTP-induced parkinsonism. Fukumitsu, N., Suzuki, M., Fukuda, T., Kiyono, Y., Kajiyama, S., Saji, H. Nucl. Med. Biol. (2006) [Pubmed]
  5. The noradrenergic system of aged GDNF heterozygous mice. Zaman, V., Li, Z., Middaugh, L., Ramamoorthy, S., Rohrer, B., Nelson, M.E., Tomac, A.C., Hoffer, B.J., Gerhardt, G.A., Granholm, A.C.h. Cell transplantation. (2003) [Pubmed]
  6. Differential expression of monoamine oxidase A, serotonin transporter, tyrosine hydroxylase and norepinephrine transporter mRNA by anorexia mutation and food deprivation. Jahng, J.W., Houpt, T.A., Joh, T.H., Son, J.H. Brain Res. Dev. Brain Res. (1998) [Pubmed]
  7. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Xu, F., Gainetdinov, R.R., Wetsel, W.C., Jones, S.R., Bohn, L.M., Miller, G.W., Wang, Y.M., Caron, M.G. Nat. Neurosci. (2000) [Pubmed]
  8. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Chen, R., Tilley, M.R., Wei, H., Zhou, F., Zhou, F.M., Ching, S., Quan, N., Stephens, R.L., Hill, E.R., Nottoli, T., Han, D.D., Gu, H.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Liu, W., Yuen, E.Y., Allen, P.B., Feng, J., Greengard, P., Yan, Z. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. Gu, H.H., Wu, X., Giros, B., Caron, M.G., Caplan, M.J., Rudnick, G. Mol. Biol. Cell (2001) [Pubmed]
  11. Exocytotic release of dopamine in ventral tegmental area slices from C57BL/6 and dopamine transporter knockout mice. John, C.E., Jones, S.R. Neurochem. Int. (2006) [Pubmed]
  12. Cloning and chromosomal mapping of the murine norepinephrine transporter. Fritz, J.D., Jayanthi, L.D., Thoreson, M.A., Blakely, R.D. J. Neurochem. (1998) [Pubmed]
  13. Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors. Gilsbach, R., Faron-Górecka, A., Rogóz, Z., Brüss, M., Caron, M.G., Dziedzicka-Wasylewska, M., Bönisch, H. J. Neurochem. (2006) [Pubmed]
  14. Catecholamine release and uptake in the mouse prefrontal cortex. Mundorf, M.L., Joseph, J.D., Austin, C.M., Caron, M.G., Wightman, R.M. J. Neurochem. (2001) [Pubmed]
  15. Ubiquitous embryonic expression of the norepinephrine transporter. Ren, Z.G., Pörzgen, P.P., Youn, Y.H., Sieber-Blum, M. Dev. Neurosci. (2003) [Pubmed]
  16. Postnatal development of the cerebellum and the CNS adrenergic system is independent of norepinephrine and epinephrine. Jin, S.H., Kim, H.J., Harris, D.C., Thomas, S.A. J. Comp. Neurol. (2004) [Pubmed]
  17. Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics. Sato, T., Kitayama, S., Mitsuhata, C., Ikeda, T., Morita, K., Dohi, T. Naunyn Schmiedebergs Arch. Pharmacol. (2000) [Pubmed]
  18. Dopamine reuptake by norepinephrine neurons: exception or rule? Carboni, E., Silvagni, A. Critical reviews in neurobiology. (2004) [Pubmed]
  19. Norepinephrine Transporter Blockade can Normalize the Prepulse Inhibition Deficits Found in Dopamine Transporter Knockout Mice. Yamashita, M., Fukushima, S., Shen, H.W., Hall, F.S., Uhl, G.R., Numachi, Y., Kobayashi, H., Sora, I. Neuropsychopharmacology (2006) [Pubmed]
  20. Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo. Weinshenker, D., White, S.S., Javors, M.A., Palmiter, R.D., Szot, P. Brain Res. (2002) [Pubmed]
  21. Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. Haughey, H.M., Kaiser, A.L., Johnson, T.E., Bennett, B., Sikela, J.M., Zahniser, N.R. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  22. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. Kolhatkar, R., Cook, C.D., Ghorai, S.K., Deschamps, J., Beardsley, P.M., Reith, M.E., Dutta, A.K. J. Med. Chem. (2004) [Pubmed]
  23. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Hall, F.S., Li, X.F., Sora, I., Xu, F., Caron, M., Lesch, K.P., Murphy, D.L., Uhl, G.R. Neuroscience (2002) [Pubmed]
  24. Altered presynaptic gene expression in transgenic mice producing dopamine in the pineal gland. Cho, S., Hwang, O., Baker, H., Baik, H.H., Volpe, B.T., Son, J.H., Joh, T.H. Synapse (1999) [Pubmed]
  25. The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice. Ahern, T.H., Javors, M.A., Eagles, D.A., Martillotti, J., Mitchell, H.A., Liles, L.C., Weinshenker, D. Neuropsychopharmacology (2006) [Pubmed]
  26. Potentiated opioid analgesia in norepinephrine transporter knock-out mice. Bohn, L.M., Xu, F., Gainetdinov, R.R., Caron, M.G. J. Neurosci. (2000) [Pubmed]
  27. Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine. Ding, Y.S., Lin, K.S., Logan, J., Benveniste, H., Carter, P. J. Neurochem. (2005) [Pubmed]
  28. Effect of antidepressant drugs in mice lacking the norepinephrine transporter. Dziedzicka-Wasylewska, M., Faron-G??recka, A., Ku??mider, M., Drozdowska, E., Rog??z, Z., Siwanowicz, J., Caron, M.G., B??nisch, H. Neuropsychopharmacology (2006) [Pubmed]
  29. Cloning and sequence analysis of the rat norepinephrine transporter promoter. Padbury, J.F., McGonnigal, B., Tseng, Y.T., Nguyen, T.T., Stabila, J.P. Brain Res. Mol. Brain Res. (2000) [Pubmed]
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