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Gene Review

SERPINE2  -  serpin peptidase inhibitor, clade E (nexin...

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High impact information on SERPINE2


Biological context of SERPINE2

  • Immunoblotting with a specific antibody raised against a fragment of SERPINE2 (S(12)-R(196)) showed that SERPINE2 migrated at 47.5 kDa in support of glycosylation [2].
  • This report demonstrates that SERPINE2 mRNA is regulated in a spatio-temporal pattern with highest levels in granulosa cells of growing dominant bovine follicles, and support the hypothesis that a high expression of SERPINE2 may contribute to follicular growth whereas a decrease following hCG injection may contribute to ovulation [2].

Associations of SERPINE2 with chemical compounds

  • As estradiol is a known marker of follicle health, and SERPINE2 is an anti-apoptotic factor, we propose that SERPINE2 is involved in the regulation of atresia in bovine follicles [1].

Regulatory relationships of SERPINE2


Other interactions of SERPINE2


Analytical, diagnostic and therapeutic context of SERPINE2

  • Semi-quantitative real-time fluorescent RT-PCR showed a six-fold increase (P = 0.0002) in mRNA level of SERPINE2 in granulosa cells of D5 dominant follicle compared to granulosa cells collected from the <or=4 mm or preovulatory hCG-induced follicles [2].


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