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Gene Review:

KLK9 - kallikrein-related peptidase 9

Homo sapiens

Synonyms: KLK-L3, KLKL3, Kallikrein-9, Kallikrein-like protein 3

Yousef, G.M. et al., Memari, N. et al., Shimizu-Okabe, C. et al., Yousef, G.M. et al., Yousef, G.M. et al.

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Disease relevance of KLK9

Our results indicate that KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines [1].
Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker [1].

High impact information on KLK9

KLK9 is a newly discovered human kallikrein gene that is expressed in several tissues including thymus, testis, spinal cord, salivary gland, ovary, and skin [1].
Recent reports have indicated that KLK9 mRNA is differentially expressed in ovarian and breast cancer and has prognostic value [2].
Full-length KLK9 cDNA was also cloned in the vector pcDNA3.1 and was expressed in CHO cells [2].
KLK9 is expressed in cortex but not hippocampus, whereas KLK2, 3, 12 and 15 are not expressed in either tissue [3].

Anatomical context of KLK9

Like other kallikreins, the KLK9 gene was found to be regulated by steroid hormones in cancer cell lines [1].

Analytical, diagnostic and therapeutic context of KLK9

We studied the expression of KLK9 by quantitative reverse transcription-PCR in 168 consecutive ovarian tumors of different stages, grades, and histological types, and correlated the expression with clinicopathological parameters, response to chemotherapy, and patients' survival [1].
EXPERIMENTAL DESIGN: We studied the expression of KLK9 by quantitative RT-PCR in 169 breast cancer patients of different stages, grades and histological types [4].
The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9) [5].

References

Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker. Yousef, G.M., Kyriakopoulou, L.G., Scorilas, A., Fracchioli, S., Ghiringhello, B., Zarghooni, M., Chang, A., Diamandis, M., Giardina, G., Hartwick, W.J., Richiardi, G., Massobrio, M., Diamandis, E.P., Katsaros, D. Cancer Res. (2001) [Pubmed]
Human tissue kallikrein 9: production of recombinant proteins and specific antibodies. Memari, N., Grass, L., Nakamura, T., Karakucuk, I., Diamandis, E.P. Biol. Chem. (2006) [Pubmed]
Expression of the kallikrein gene family in normal and Alzheimer's disease brain. Shimizu-Okabe, C., Yousef, G.M., Diamandis, E.P., Yoshida, S., Shiosaka, S., Fahnestock, M. Neuroreport (2001) [Pubmed]
The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer. Yousef, G.M., Scorilas, A., Nakamura, T., Ellatif, M.A., Ponzone, R., Biglia, N., Maggiorotto, F., Roagna, R., Sismondi, P., Diamandis, E.P. Breast Cancer Res. Treat. (2003) [Pubmed]
The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9). Yousef, G.M., Diamandis, E.P. Genomics (2000) [Pubmed]

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