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Gene Review

KLK9  -  kallikrein-related peptidase 9

Homo sapiens

Synonyms: KLK-L3, KLKL3, Kallikrein-9, Kallikrein-like protein 3
 
 
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Disease relevance of KLK9

 

High impact information on KLK9

 

Anatomical context of KLK9

 

Analytical, diagnostic and therapeutic context of KLK9

  • We studied the expression of KLK9 by quantitative reverse transcription-PCR in 168 consecutive ovarian tumors of different stages, grades, and histological types, and correlated the expression with clinicopathological parameters, response to chemotherapy, and patients' survival [1].
  • EXPERIMENTAL DESIGN: We studied the expression of KLK9 by quantitative RT-PCR in 169 breast cancer patients of different stages, grades and histological types [4].
  • The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9) [5].

References

  1. Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker. Yousef, G.M., Kyriakopoulou, L.G., Scorilas, A., Fracchioli, S., Ghiringhello, B., Zarghooni, M., Chang, A., Diamandis, M., Giardina, G., Hartwick, W.J., Richiardi, G., Massobrio, M., Diamandis, E.P., Katsaros, D. Cancer Res. (2001) [Pubmed]
  2. Human tissue kallikrein 9: production of recombinant proteins and specific antibodies. Memari, N., Grass, L., Nakamura, T., Karakucuk, I., Diamandis, E.P. Biol. Chem. (2006) [Pubmed]
  3. Expression of the kallikrein gene family in normal and Alzheimer's disease brain. Shimizu-Okabe, C., Yousef, G.M., Diamandis, E.P., Yoshida, S., Shiosaka, S., Fahnestock, M. Neuroreport (2001) [Pubmed]
  4. The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer. Yousef, G.M., Scorilas, A., Nakamura, T., Ellatif, M.A., Ponzone, R., Biglia, N., Maggiorotto, F., Roagna, R., Sismondi, P., Diamandis, E.P. Breast Cancer Res. Treat. (2003) [Pubmed]
  5. The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9). Yousef, G.M., Diamandis, E.P. Genomics (2000) [Pubmed]
 
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