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Gene Review

Thbs2  -  thrombospondin 2

Rattus norvegicus

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Disease relevance of Thbs2


High impact information on Thbs2

  • Similarly, interference with the Smad2/3/4 pathway using dexamethasone also heavily decreased expression of collagen type I and TSP-2 whereas transdifferentiation of HSC to the typical morphology of MFB with loss of fat droplets and increasing alpha-SMA was unchanged [3].
  • Decreased expressions of thrombospondin 2 in cyclosporin A-induced gingival overgrowth [2].
  • Western blot analyses showed that the expression of TSP2 protein was dose-dependently reduced by the CsA treatments in human cultured gingival fibroblasts [2].
  • 24 genes of known function (thrombospondin-2, vimentin, etc.), 13 genes of known sequence but unknown function including 7 of ESTs (SNERG1, rat GPCR, etc.), and 2 novel genes [4].


  1. Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion. Lin, T.N., Kim, G.M., Chen, J.J., Cheung, W.M., He, Y.Y., Hsu, C.Y. Stroke (2003) [Pubmed]
  2. Decreased expressions of thrombospondin 2 in cyclosporin A-induced gingival overgrowth. Koh, J.T., Kim, O.J., Park, Y.S., Kim, S.H., Kim, W.J., Chung, H.J., Lee, S.E., Jeong, B.C., Jung, J.Y., Kim, K.K. J. Periodont. Res. (2004) [Pubmed]
  3. Transdifferentiation-dependent expression of alpha-SMA in hepatic stellate cells does not involve TGF-beta pathways leading to coinduction of collagen type I and thrombospondin-2. Lindert, S., Wickert, L., Sawitza, I., Wiercinska, E., Gressner, A.M., Dooley, S., Breitkopf, K. Matrix Biol. (2005) [Pubmed]
  4. Analysis of genes dominantly expressed in rat cerebral endothelial cells using suppression subtractive hybridization. Shibata, T., Misawa, N., Takeo, C., Saeki, N., Saito, Y., Tatsuno, I. J. Atheroscler. Thromb. (2005) [Pubmed]
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