Gene Review:
Thbs1 - thrombospondin 1
Rattus norvegicus
Synonyms:
TSP-1, Tsp1
- Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions. Zhou, Y., Poczatek, M.H., Berecek, K.H., Murphy-Ullrich, J.E. Biochem. Biophys. Res. Commun. (2006)
- Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model. Hugo, C., Kang, D.H., Johnson, R.J. Nephron (2002)
- Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion. Lin, T.N., Kim, G.M., Chen, J.J., Cheung, W.M., He, Y.Y., Hsu, C.Y. Stroke (2003)
- Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat. Hugo, C., Shankland, S.J., Pichler, R.H., Couser, W.G., Johnson, R.J. Kidney Int. (1998)
- F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension. Klar, A., Baldassare, M., Jessell, T.M. Cell (1992)
- Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia. Thakar, C.V., Zahedi, K., Revelo, M.P., Wang, Z., Burnham, C.E., Barone, S., Bevans, S., Lentsch, A.B., Rabb, H., Soleimani, M. J. Clin. Invest. (2005)
- Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth. DeFreitas, M.F., Yoshida, C.K., Frazier, W.A., Mendrick, D.L., Kypta, R.M., Reichardt, L.F. Neuron (1995)
- Inhibition of retinal angiogenesis by peptides derived from thrombospondin-1. Shafiee, A., Penn, J.S., Krutzsch, H.C., Inman, J.K., Roberts, D.D., Blake, D.A. Invest. Ophthalmol. Vis. Sci. (2000)
- Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis. Suzuki, K., Wang, R., Kubota, H., Shibuya, H., Saegusa, J., Sato, T. Exp. Mol. Pathol. (2005)
- Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity. Wang, S., Wu, X., Lincoln, T.M., Murphy-Ullrich, J.E. Diabetes (2003)
- Androgens repress the expression of the angiogenesis inhibitor thrombospondin-1 in normal and neoplastic prostate. Colombel, M., Filleur, S., Fournier, P., Merle, C., Guglielmi, J., Courtin, A., Degeorges, A., Serre, C.M., Bouvier, R., Clézardin, P., Cabon, F. Cancer Res. (2005)
- Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2. Wang, S., Skorczewski, J., Feng, X., Mei, L., Murphy-Ullrich, J.E. J. Biol. Chem. (2004)
- Role of thrombospondin in mesangial cell growth: possible existence of an autocrine feedback growth circuit. Marinides, G.N., Suchard, S.J., Mookerjee, B.K. Kidney Int. (1994)
- Characterization of intracellular pathways leading to coinduction of thrombospondin-1 and TGF-beta1 expression in rat hepatic stellate cells. Breitkopf, K., Sawitza, I., Gressner, A.M. Growth Factors (2005)
- Differential expression of thrombospondin and cellular fibronectin during remodeling in proliferative glomerulonephritis. Barnes, J.L., Mitchell, R.J., Kanalas, J.J., Barnes, V.L. J. Histochem. Cytochem. (1999)
- A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat. Yehualaeshet, T., O'Connor, R., Begleiter, A., Murphy-Ullrich, J.E., Silverstein, R., Khalil, N. Am. J. Respir. Cell Mol. Biol. (2000)
- Autocrine thrombospondin partially mediates TGF-beta1- induced proliferation of vascular smooth muscle cells. Sajid, M., Lele, M., Stouffer, G.A. Am. J. Physiol. Heart Circ. Physiol. (2000)
- The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. Schultz-Cherry, S., Lawler, J., Murphy-Ullrich, J.E. J. Biol. Chem. (1994)
- Microglia enhance dorsal root ganglion outgrowth in Schwann cell cultures. Hynds, D.L., Rangappa, N., Ter Beest, J., Snow, D.M., Rabchevsky, A.G. Glia (2004)
- Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo. Daniel, C., Wiede, J., Krutzsch, H.C., Ribeiro, S.M., Roberts, D.D., Murphy-Ullrich, J.E., Hugo, C. Kidney Int. (2004)
- 1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression. Li, Y., Spataro, B.C., Yang, J., Dai, C., Liu, Y. Kidney Int. (2005)
- Induction of transforming growth factor-beta autocrine activity by all-trans-retinoic acid and 1 alpha,25-dihydroxyvitamin D3 in NRP-152 rat prostatic epithelial cells. Danielpour, D. J. Cell. Physiol. (1996)
- Changes in the immunohistochemical localisation of fibroblast growth factor-2, transforming growth factor-beta 1 and thrombospondin-1 are associated with early angiogenic events in the hyperplastic rat thyroid. Patel, V.A., Hill, D.J., Eggo, M.C., Sheppard, M.C., Becks, G.P., Logan, A. J. Endocrinol. (1996)
- Thrombospondin is an osteoblast-derived component of mineralized extracellular matrix. Robey, P.G., Young, M.F., Fisher, L.W., McClain, T.D. J. Cell Biol. (1989)