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Gene Review

GRSF1  -  G-rich RNA sequence binding factor 1

Homo sapiens

Synonyms: G-rich sequence factor 1, GRSF-1
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Disease relevance of GRSF1

  • Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis [1].
  • Using the 5' UTR of the influenza virus nucleocapsid protein (NP) mRNA as bait, we identified the cellular RNA-recognition motif containing RNA-binding protein G-rich sequence factor 1 (GRSF-1) as a positive-acting translational regulatory factor [2].

High impact information on GRSF1

  • Taken together, these data document the functional demonstration of a cellular protein binding to influenza virus RNAs and, importantly, suggest that influenza virus may recruit GRSF-1 to the 5' UTR to ensure preferential translation of viral mRNAs in infected cells [2].
  • Furthermore, translation efficiency of NP 5' UTR-driven templates was reduced markedly in GRSF-1-depleted HeLa cell extracts, but restored in GRSF-1-reconstituted extracts [2].
  • Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1 [2].
  • In the present study, we have characterized the functional domains of GRSF-1 and mapped the RNA binding activity of GRSF-1 to RRM 2 (amino acids 194 to 275) with amino-terminal deletion glutathione S-transferase (GST)-GRSF-1 proteins [1].
  • We have also mapped the GRSF-1 RNA binding site on influenza virus NP and NS1 5' UTRs, which was determined to be the sequence AGGGU [1].

Biological context of GRSF1


Other interactions of GRSF1

  • Taken together, these studies demonstrate that RRM 2 is critical for GRSF-1 RNA binding and translational activity [1].

Analytical, diagnostic and therapeutic context of GRSF1


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