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Gene Review

Lasp1  -  LIM and SH3 protein 1

Rattus norvegicus

Synonyms: LASP-1, LIM and SH3 domain protein 1
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High impact information on Lasp1


Biological context of Lasp1

  • Because cAMP is a potent stimulator of parietal cell acid secretion, we have hypothesized that changes in lasp-1 phosphorylation might be involved in the regulation of ion transport-related activities, perhaps by modulating interactions among cytoskeletal and/or vesicle-associated proteins [2].
  • For example, gastric chief cells, which contain relatively little F-actin and secrete the enzyme, pepsinogen, by regulated exocytosis, do not appear to express lasp-1 [2].
  • Localisation of fascin, the LIM and SH3 domain protein 1 (lasp-1), and lasp-2 to the bundles suggest their involvement in that organisation; however, their contributions remain unclear [3].

Anatomical context of Lasp1


  1. AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Spence, H.J., McGarry, L., Chew, C.S., Carragher, N.O., Scott-Carragher, L.A., Yuan, Z., Croft, D.R., Olson, M.F., Frame, M., Ozanne, B.W. Mol. Cell. Biol. (2006) [Pubmed]
  2. The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia. Chew, C.S., Parente, J.A., Chen, X., Chaponnier, C., Cameron, R.S. J. Cell. Sci. (2000) [Pubmed]
  3. Short-term retention of actin filament binding proteins on lamellipodial actin bundles. Nakagawa, H., Terasaki, A.G., Suzuki, H., Ohashi, K., Miyamoto, S. FEBS Lett. (2006) [Pubmed]
  4. Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines. Phillips, G.R., Anderson, T.R., Florens, L., Gudas, C., Magda, G., Yates, J.R., Colman, D.R. J. Neurosci. Res. (2004) [Pubmed]
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