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MeSH Review

Chief Cells, Gastric

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Disease relevance of Chief Cells, Gastric


High impact information on Chief Cells, Gastric


Biological context of Chief Cells, Gastric


Anatomical context of Chief Cells, Gastric


Associations of Chief Cells, Gastric with chemical compounds


Gene context of Chief Cells, Gastric

  • Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors [18].
  • These data clearly indicate that, in gastric chief cells, a mixture of M1 and M3 receptors mediates cholinergic stimulation of pepsinogen secretion and that no other muscarinic receptor subtypes are involved in this activity [18].
  • Functional localization of proprotein-convertase furin and its substrate TGFbeta in EGF receptor-expressing gastric chief cells [19].
  • Gastric chief cells were isolated from the rat stomach in an attempt to identify those involved in the mechanism of action of somatostatin on pepsinogen secretion [20].
  • In gastric chief cells, PYY and NPY attenuate the stimulatory effects of secretagogues whose actions are mediated by changes in cellular levels of cAMP [21].

Analytical, diagnostic and therapeutic context of Chief Cells, Gastric


  1. Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats. Fiorucci, S., Antonelli, E., Santucci, L., Morelli, O., Miglietti, M., Federici, B., Mannucci, R., Del Soldato, P., Morelli, A. Gastroenterology (1999) [Pubmed]
  2. Inhibitory action of somatostatin on cAMP dependent pepsinogen secretion from rat gastric chief cells: involvement of pertussis toxin-sensitive G-protein. Tanaka, T., Tani, S. Biol. Pharm. Bull. (1994) [Pubmed]
  3. Prostaglandin protects isolated guinea pig chief cells against ethanol injury via an increase in diacylglycerol. Konda, Y., Nishisaki, H., Nakano, O., Matsuda, K., Wada, K., Nagao, M., Matozaki, T., Sakamoto, C. J. Clin. Invest. (1990) [Pubmed]
  4. Epidermal growth factor modulates pepsinogen secretion in guinea pig gastric chief cells. Fiorucci, S., Lanfrancone, L., Santucci, L., Calabro, A., Orsini, B., Federici, B., Morelli, A. Gastroenterology (1996) [Pubmed]
  5. Motilin and erythromycin stimulate pepsinogen secretion by chief cells isolated from guinea pig stomach. Fiorucci, S., Morelli, A. Gastroenterology (1993) [Pubmed]
  6. Ethanol stimulates pepsinogen release by opening a Ca2+ channel of guinea pig gastric chief cells. Konda, Y., Sakamoto, C., Nishisaki, H., Nakano, O., Matozaki, T., Nagao, M., Matsuda, K., Wada, K., Baba, S. Gastroenterology (1991) [Pubmed]
  7. The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia. Chew, C.S., Parente, J.A., Chen, X., Chaponnier, C., Cameron, R.S. J. Cell. Sci. (2000) [Pubmed]
  8. Isolated guinea pig gastric chief cells express tumour necrosis factor receptors coupled with the sphingomyelin pathway. Fiorucci, S., Santucci, L., Migliorati, G., Riccardi, C., Amorosi, A., Mancini, A., Roberti, R., Morelli, A. Gut (1996) [Pubmed]
  9. Expression and phosphorylation of a MARCKS-like protein in gastric chief cells: further evidence for modulation of pepsinogen secretion by interaction of Ca2+/calmodulin with protein kinase C. Raufman, J.P., Malhotra, R., Xie, Q., Raffaniello, R.D. J. Cell. Biochem. (1997) [Pubmed]
  10. Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. Fiorucci, S., Santucci, L., Gresele, P., Luinetti, O., Morelli, A. Am. J. Physiol. (1995) [Pubmed]
  11. Characterization of cholecystokinin receptors on guinea pig gastric chief cell membranes. Matozaki, T., Sakamoto, C., Nagao, M., Nishisaki, H., Konda, Y., Nakano, O., Matsuda, K., Wada, K., Suzuki, T., Kasuga, M. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  12. Reappraisal of potassium permanganate oxidation applied to Lowicryl K4M embedded tissues processed by high pressure freezing/freeze substitution, with special reference to differential staining of the zymogen granules of rat gastric chief cells. Sawaguchi, A., Ide, S., Kawano, J., Nagaike, R., Oinuma, T., Tojo, H., Okamoto, M., Suganuma, T. Arch. Histol. Cytol. (1999) [Pubmed]
  13. Fluorescence histochemistry of peptide hormone-producing cells: observations on the phenanthrenequinone method for the demonstration of arginine residues. Sundler, F., Håkanson, R. Histochemistry (1978) [Pubmed]
  14. rab3D protein is a specific marker for zymogen granules in gastric chief cells of rats and rabbits. Tang, L.H., Gumkowski, F.D., Sengupta, D., Modlin, I.M., Jamieson, J.D. Gastroenterology (1996) [Pubmed]
  15. Electrical effects of histamine on monolayers formed in culture from enriched canine gastric chief cells. Ayalon, A., Sanders, M.J., Thomas, L.P., Amirian, D.A., Soll, A.H. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  16. Guanine nucleotides activate multiple signaling pathways in permeabilized gastric chief cells. Evidence for GTP gamma S-induced calcium-independent pepsinogen secretion. Raffaniello, R.D., Raufman, J.P. J. Biol. Chem. (1993) [Pubmed]
  17. Calcineurin mediates calcium-induced potentiation of adenylyl cyclase activity in dispersed chief cells from guinea pig stomach. Further evidence for cross-talk between signal transduction pathways that regulate pepsinogen secretion. Raufman, J.P., Lin, J., Raffaniello, R.D. J. Biol. Chem. (1996) [Pubmed]
  18. Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors. Xie, G., Drachenberg, C., Yamada, M., Wess, J., Raufman, J.P. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  19. Functional localization of proprotein-convertase furin and its substrate TGFbeta in EGF receptor-expressing gastric chief cells. Fujisawa, T., Kamimura, H., Hosaka, M., Torii, S., Izumi, T., Kuwano, H., Takeuchi, T. Growth Factors (2004) [Pubmed]
  20. Somatostatin inhibits pepsinogen secretion without influencing cytosolic free Ca2+ increase induced by carbachol and cholecystokinin octapeptide in rat chief cells. Tanaka, T., Miyadera, K., Tani, S. Biol. Pharm. Bull. (1993) [Pubmed]
  21. Actions of peptide YY and neuropeptide Y on chief cells from guinea pig stomach. Raufman, J.P., Singh, L. Am. J. Physiol. (1991) [Pubmed]
  22. Hormonal effects on development of the secretory apparatus of chief cells. Tseng, C.C., Schmidt, K.L., Johnson, L.R. Am. J. Physiol. (1987) [Pubmed]
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